2-(Aminomethyl)morpholine

Base Information

• Chemical Name: 2-(Aminomethyl)morpholine
• CAS No.: 116143-27-2
• Molecular Formula: C5H12N2O
• Molecular Weight: 116.163
• Hs Code.: 2934999090
• European Community (EC) Number: 856-472-0
• ChEMBL ID: CHEMBL4539072
• DSSTox Substance ID: DTXSID60404080
• Mol file: 116143-27-2.mol

Synonyms:2-(Aminomethyl)morpholine;116143-27-2;morpholin-2-ylmethanamine;2-Morpholinemethanamine;Morpholin-2-yl-methylamine;2-Aminomethylmorpholine;(morpholin-2-yl)methanamine;(morpholin-2-ylmethyl)amine dihydrochloride;MFCD03990581;1-MORPHOLIN-2-YLMETHANAMINE;morpholin-2-ylmethylamine;2-morpholinylmethanamine;Morpholine-2-methanamine;2-(aminomethyl)-morpholine;SCHEMBL1267090;CHEMBL4539072;DTXSID60404080;OXYALYJRWGRVAM-UHFFFAOYSA-N;BCP32713;2-(Aminomethyl)morpholine, AldrichCPR;AKOS009249669;PB15765;PS-3308;SY005409;AM20080111;CS-0046184;FT-0685129;EN300-141075;A803565;J-510120

Chemical Property of 2-(Aminomethyl)morpholine

Chemical Property:

• Vapor Pressure: 0.291mmHg at 25°C
• Refractive Index: 1.447
• Boiling Point: 202.5 °C at 760 mmHg
• Flash Point: 76.3 °C
• PSA: 47.28000
• Density: 0.982g/cm³
• LogP: -0.03740
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 116.094963011
• Heavy Atom Count: 8
• Complexity: 67.4

Purity/Quality:

98%min ^*data from raw suppliers

2-(Aminomethyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)CN

Technology Process of 2-(Aminomethyl)morpholine

There total 1 articles about 2-(Aminomethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C5H13N2O5S(1-)*K(1+) → 1-morpholin-2-ylmethanamine (116143-27-2)

Guidance literature:

With sulfuric acid; at 150 ℃; for 5h;

DOI:10.1007/BF02494855

Reference yield: 92.0%

4-amino-5-chloro-2-ethoxybenzoic acid (108282-38-8) + 1-morpholin-2-ylmethanamine (116143-27-2) → Des-4-fluorobenzyl Mosapride (152013-26-8)

Guidance literature:

1-morpholin-2-ylmethanamine; With triethylamine; isobutyl chloroformate; In dichloromethane; at -10 ℃; for 0.166667h;

4-amino-5-chloro-2-ethoxybenzoic acid; In dichloromethane; at -10 - 20 ℃; for 4h;

Reference yield: 53.0%

1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (728034-12-6) + 1-((4-fluorophenyl)(isocyano)methylsulfonyl)-4-methylbenzene (165806-95-1) + 1-morpholin-2-ylmethanamine (116143-27-2) → 2-((4-(4-fluorophenyl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-imidazol-1-yl)methyl)morpholine

Guidance literature:

1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde; 1-morpholin-2-ylmethanamine; In N,N-dimethyl-formamide; at 25 ℃; for 3h;

1-((4-fluorophenyl)(isocyano)methylsulfonyl)-4-methylbenzene; With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

Downstream raw materials:

Des-4-fluorobenzyl Mosapride

Refernces