N-(4-Chlorophenyl)-6-methoxy-3,4-dihydroquinoline-1(2H)-carboximidamide

Base Information

• Chemical Name: N-(4-Chlorophenyl)-6-methoxy-3,4-dihydroquinoline-1(2H)-carboximidamide
• CAS No.: 6943-27-7
• Molecular Formula: C₁₇H₁₈ClN₃O
• Molecular Weight: 315.802
• NSC Number: 51683
• ChEMBL ID: CHEMBL1508995
• Mol file: 6943-27-7.mol

Synonyms:NSC51683;MLS000737284;N-(4-Chlorophenyl)-6-methoxy-3,4-dihydroquinoline-1(2H)-carboximidamide;6943-27-7;CHEMBL1508995;NSC-51683;SMR000528249

Chemical Property of N-(4-Chlorophenyl)-6-methoxy-3,4-dihydroquinoline-1(2H)-carboximidamide

Chemical Property:

• Boiling Point: 501.6°Cat760mmHg
• Flash Point: 257.2°C
• Density: 1.27g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 315.1138399
• Heavy Atom Count: 22
• Complexity: 395

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)N(CCC2)C(=NC3=CC=C(C=C3)Cl)N

Technology Process of N-(4-Chlorophenyl)-6-methoxy-3,4-dihydroquinoline-1(2H)-carboximidamide

There total 2 articles about N-(4-Chlorophenyl)-6-methoxy-3,4-dihydroquinoline-1(2H)-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-1,2,3,4-tetrahydroquinoline (120-15-0) → 6-methoxy-3,4-dihydro-2H-quinoline-1-carbonimidic acid-(4-chloro-anilide) (6943-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene

With benzene;

DOI:10.1021/ja01132a508

Reference yield:

6-methoxy-3,4-dihydroquinoline-1(2H)-carbonitrile (860204-90-6) + p-chloroaniline hydrochloride (20265-96-7) → 6-methoxy-3,4-dihydro-2H-quinoline-1-carbonimidic acid-(4-chloro-anilide) (6943-27-7)

Guidance literature:

DOI:10.1021/ja01132a508

upstream raw materials:

6-methoxy-3,4-dihydroquinoline-1(2H)-carbonitrile

p-chloroaniline hydrochloride

6-methoxy-1,2,3,4-tetrahydroquinoline