Technology Process of (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R,3E,5S)-5-methylhept-3-en-2-yl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (non-preferred name)
There total 18 articles about (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R,3E,5S)-5-methylhept-3-en-2-yl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (non-preferred name) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
2: 885 mg / sodium bis(2-methoxyethoxy)aluminum hydride (Red-Al, 70percent in toluene) / diethyl ether / 48 h / Heating
3: 774 mg / propionic acid / xylene / 2 h / 130 °C
4: 503 mg / lithium aluminum hydride / diethyl ether / 1 h / Heating
5: 521 mg / pyridine / Ambient temperature; overnight
6: 290 mg / lithium aluminum hydride / tetrahydrofuran / 1 h / Heating
7: 216 mg / p-toluenesulfonic acid / dioxane; H2O / 1 h / Heating
With
lithium aluminium tetrahydride; toluene-4-sulfonic acid; propionic acid; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; 1,4-dioxane; pyridine; diethyl ether; water; xylene;
DOI:10.1021/jo00133a036
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 0.969 g / H2, quinoline / Lindlar catalyst / hexane / 3 h / Ambient temperature
2: 481 mg / propionic acid / xylene / 2 h / 130 °C
3: 503 mg / lithium aluminum hydride / diethyl ether / 1 h / Heating
4: 521 mg / pyridine / Ambient temperature; overnight
5: 290 mg / lithium aluminum hydride / tetrahydrofuran / 1 h / Heating
6: 216 mg / p-toluenesulfonic acid / dioxane; H2O / 1 h / Heating
With
quinoline; lithium aluminium tetrahydride; hydrogen; toluene-4-sulfonic acid; propionic acid;
Lindlar's catalyst;
In
tetrahydrofuran; 1,4-dioxane; pyridine; diethyl ether; hexane; water; xylene;
DOI:10.1021/jo00133a036
- Guidance literature:
-
Multi-step reaction with 7 steps
2: 90 percent / quinoline / Lindlar catalyst
3: 65 percent / propionic acid / toluene / Heating
4: LiAlH4
5: triethylamine
6: LiAlH4
7: H(1+)
With
quinoline; lithium aluminium tetrahydride; hydrogen cation; propionic acid; triethylamine;
Lindlar's catalyst;
In
toluene;
DOI:10.1016/S0040-4039(01)90046-2
