6-Methyl-5-(morpholin-4-ylmethyl)pyrimidine-2,4-diol

Base Information

• Chemical Name: 6-Methyl-5-(morpholin-4-ylmethyl)pyrimidine-2,4-diol
• CAS No.: 23213-33-4
• Molecular Formula: C₁₀H₁₅N₃O₃
• Molecular Weight: 225.247
• NSC Number: 40227
• DSSTox Substance ID: DTXSID40285016
• Wikidata: Q82020228
• ChEMBL ID: CHEMBL4956677
• Mol file: 23213-33-4.mol

Synonyms:23213-33-4;6-methyl-5-(morpholin-4-ylmethyl)pyrimidine-2,4-diol;NSC40227;Oprea1_689676;Oprea1_786910;CHEMBL4956677;SCHEMBL14123251;6-methyl-5-morpholinomethyluracil;DTXSID40285016;NSC-40227;AKOS002317562;AKOS002663017

Chemical Property of 6-Methyl-5-(morpholin-4-ylmethyl)pyrimidine-2,4-diol

Chemical Property:

• Vapor Pressure: 1.98E-09mmHg at 25°C
• Boiling Point: 469.3°C at 760 mmHg
• Flash Point: 237.6°C
• Density: 1.231g/cm³
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 225.11134135
• Heavy Atom Count: 16
• Complexity: 345

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=O)NC(=O)N1)CN2CCOCC2

Technology Process of 6-Methyl-5-(morpholin-4-ylmethyl)pyrimidine-2,4-diol

There total 2 articles about 6-Methyl-5-(morpholin-4-ylmethyl)pyrimidine-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) + 6-Methyluracil (626-48-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → C-5-Morpholinomethylene-6-methyluracil (23213-33-4)

Guidance literature:

In ethanol; water; for 6h; Reflux;

DOI:10.1007/s11172-010-0138-8

Reference yield:

→ 6-methyl-5-morpholin-4-ylmethyl-1H-pyrimidine-2,4-dione (23213-33-4)

Guidance literature:

Chlorid, Morpholin;

upstream raw materials:

morpholine

6-Methyluracil

formaldehyd