10-HYDROXY-9-NITROCAMPTOTHECIN

Base Information

Chemical Name:10-HYDROXY-9-NITROCAMPTOTHECIN
CAS No.:104267-73-4
Molecular Formula:C20H15 N3 O7
Molecular Weight:409.355
Hs Code.:
Mol file:104267-73-4.mol

Synonyms:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-10-nitro-, (S)-; 9-Hydroxy-10-nitrocamptothecin

Suppliers and Price of 10-HYDROXY-9-NITROCAMPTOTHECIN

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
9-NITRO-10-HYDROXYCAMPTOTHECIN 95.00%
5MG
$ 500.17

Total 14 raw suppliers

Chemical Property of 10-HYDROXY-9-NITROCAMPTOTHECIN

Chemical Property:

Vapor Pressure:7.58E-29mmHg at 25°C
Melting Point:205-208℃
Boiling Point:825.3°Cat760mmHg
Flash Point:452.9°C
PSA：147.47000
Density:1.71g/cm³
LogP:2.21660

Purity/Quality:

98%,99%, ^*data from raw suppliers

9-NITRO-10-HYDROXYCAMPTOTHECIN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 10-HYDROXY-9-NITROCAMPTOTHECIN

There total 3 articles about 10-HYDROXY-9-NITROCAMPTOTHECIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 19685-09-7,64439-81-2
(S)-10-hydroxycamptothecin

: 104267-73-4
9-nitro-10-hydroxy-20(S)-camptothecin

Guidance literature:: With nitric acid; In sulfuric acid; Ambient temperature;
DOI:10.1016/0960-894X(96)00083-2

Reference yield:

: 7689-03-4,91926-09-9
camptothecin

: 104267-73-4
9-nitro-10-hydroxy-20(S)-camptothecin

Guidance literature:: Multi-step reaction with 3 steps

1: H₂; AcOH / PtO₂ / dimethylsulfoxide

2: PhI(OAc)2; aq. AcOH

3: 83 percent / HNO₃; AcOH / ethyl acetate / 1 h

With [bis(acetoxy)iodo]benzene; hydrogen; nitric acid; acetic acid; platinum(IV) oxide; In dimethyl sulfoxide; ethyl acetate;
DOI:10.1055/s-2006-942359

Reference yield:

: 870527-52-9
1,2,6,7-tetrahydro-(20S)-camphthotecine

: 104267-73-4
9-nitro-10-hydroxy-20(S)-camptothecin

Guidance literature:: Multi-step reaction with 2 steps

1: PhI(OAc)2; aq. AcOH

2: 83 percent / HNO₃; AcOH / ethyl acetate / 1 h

With [bis(acetoxy)iodo]benzene; nitric acid; acetic acid; In ethyl acetate;
DOI:10.1055/s-2006-942359