Chemical Property of 10-Hydroxycamptothecin
Chemical Property:
- Appearance/Colour:Yellow solid
- Vapor Pressure:1.67E-28mmHg at 25°C
- Melting Point:265-270 °C
- Refractive Index:1.776
- Boiling Point:820.7 °C at 760 mmHg
- PKA:8.93±0.40(Predicted)
- Flash Point:450.1 °C
- PSA：101.65000
- Density:1.6 g/cm3
- LogP:1.78520
- Storage Temp.:-20°C Freezer
- Solubility.:≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
- XLogP3:0.6
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:1
- Exact Mass:364.10592162
- Heavy Atom Count:27
- Complexity:774
- Purity/Quality:
-
99% *data from raw suppliers
SN 38 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
- Isomeric SMILES:CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
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Description
DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.
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Uses
A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy
