Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, methyl ester

Base Information

• Chemical Name: Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, methyl ester
• CAS No.: 92638-18-1
• Molecular Formula: C17H15F2NO5
• Molecular Weight: 351.3015064
• Mol file: 92638-18-1.mol

Synonyms:Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, methyl ester;IOS 2069;BRN 3630965;SCHEMBL16415757;UCYAQFHJRBNFRN-UHFFFAOYSA-N;92638-18-1

Chemical Property of Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, methyl ester

Chemical Property:

• PSA: 73.86000
• LogP: 2.56150
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 351.09182890
• Heavy Atom Count: 25
• Complexity: 643

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(C2=C(N1)COC2=O)C3=CC=CC=C3OC(F)F)C(=O)OC

Technology Process of Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, methyl ester

There total 2 articles about Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Riodipine (71653-63-9) → 2-Methyl-3-methoxycarbonyl-5-oxo-4-(2'-difluoromethoxyphenyl)-1,4,5,7-tetrahydrofuro<3,4-b>pyridine (92638-18-1)

Guidance literature:

With N-Bromosuccinimide; In chloroform; 1) 1h 2) 2h, reflux;

DOI:10.1007/BF00472752

Reference yield: 58.0%

pyridinium hydrobromide perbromide (39416-48-3,91113-93-8) + Riodipine (71653-63-9) → 2-Methyl-3-methoxycarbonyl-5-oxo-4-(2'-difluoromethoxyphenyl)-1,4,5,7-tetrahydrofuro<3,4-b>pyridine (92638-18-1) + N-<2-Methyl-3,5-dimethoxycarbonyl-4-(2'-difluoromethoxyphenyl)-1,4-dihydropyridine-6-methylene>pyridinium bromide (126382-65-8)

Guidance literature:

In pyridine; chloroform; 1) 5 deg C, 30 min 2) 90 min, reflux;

DOI:10.1007/BF00472752

Reference yield: 46.0%

2-Methyl-3-methoxycarbonyl-5-oxo-4-(2'-difluoromethoxyphenyl)-1,4,5,7-tetrahydrofuro<3,4-b>pyridine (92638-18-1) → 2-bromomethyl-1,4,5,7-tetrahydro-4-(2-difluoromethoxyphenyl)-3-(methoxycarbonyl)furo<3,4-b>pyridine (140845-62-1)

Guidance literature:

With N-Bromosuccinimide; In methanol; for 1h; Ambient temperature;

DOI:10.1007/BF00484364

upstream raw materials:

pyridinium hydrobromide perbromide

Riodipine

Downstream raw materials:

2-bromomethyl-1,4,5,7-tetrahydro-4-(2-difluoromethoxyphenyl)-3-(methoxycarbonyl)furo<3,4-b>pyridine