71653-63-9

Basic information

• Product Name: Riodipine
• Synonyms: Riodipine;ryodipine;dimethyl 4-(2-(difluoromethoxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 71653-63-9
• Molecular Formula: C₁₈H₁₉F₂NO₅
• Molecular Weight: 367.346
• Mol File: 71653-63-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 157°C
• Boiling Point: 445.4°C at 760 mmHg
• Flash Point: 223.2°C
• Appearance: /
• Density: 1.2786 (estimate)
• Vapor Pressure: 3.97E-08mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: Riodipine(CAS DataBase Reference)
• NIST Chemistry Reference: Riodipine(71653-63-9)
• EPA Substance Registry System: Riodipine(71653-63-9)

Safety Data

• Hazardous Substances Data: 71653-63-9(Hazardous Substances Data)

Usage

Uses

Replenisher (fluid); replenisher (electrolyte).

InChI:InChI=1/C18H19F2NO5/c1-9-13(16(22)24-3)15(14(10(2)21-9)17(23)25-4)11-7-5-6-8-12(11)26-18(19)20/h5-8,15,18,21H,1-4H3

Upstream product

• 71653-64-0 o-difluoromethoxybenzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 92638-18-1 2-Methyl-3-methoxycarbonyl-5-oxo-4-(2'-difluoromethoxyphenyl)-1,4,5,7-tetrahydrofuro<3,4-b>pyridine 
• 126382-65-8 N-<2-Methyl-3,5-dimethoxycarbonyl-4-(2'-difluoromethoxyphenyl)-1,4-dihydropyridine-6-methylene>pyridinium bromide 
• 126382-66-9 1,7-Dioxo-8-(2'-difluoromethoxyphenyl)-1,3,4,5,7,8-hexahydro(difuro)-<3,4-b; 3',4'-e>pyridine 
• 140845-69-8 2-Dibromomethyl-3-methoxycarbonyl-5-oxo-4-(2'-difluoromethoxyphenyl)-1,4,5,7-tetrahydrofuro<3,4-b>pyridine 
• 126382-68-1 2,6-Bis(dibromomethyl)-3,5-dimethoxycarbonyl-4-(2'-difluoromethoxyphenyl)-1,4-dihydropyridine 
• 111169-84-7 4-(2-Difluoromethoxy-4-nitro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 129303-76-0 2-dichloromethylen-3,5-dicarbomethoxy-3,5-dichloro-4-(2'-difluoromethoxyphenyl)-6-dichloromethyl-2,3,4,5-tetrahydropyridine 
• 129303-75-9 2-chloromethylen-3,5-dicarbomethoxy-3,5-dichloro-4-(2'-difluoromethoxyphenyl)-6-dichloromethyl-2,3,4,5-tetrahydropyridine 
• 129303-77-1 2-dichloromethylen-3,5-dicarbomethoxy-3,5-dichloro-4-(2'-difluoromethoxyphenyl)-6-trichloromethyl-2,3,4,5-tetrahydropyridine 
• 97744-29-1 Methyl 2,4-dimethyl-5-oxo-5H-<1>benzopyrano<3,4-c>pyridine-1-carboxylate 
• 97744-33-7 3,5-dimethoxycarbonyl-2,6-dimethyl-4-(o-difluoromethoxyphenyl)-pyridine 
• 97744-30-4 2,6-dimethyl-4-(o-difluoromethoxyphenyl)-pyridine-3,5-dicarbonic acid 
• 97744-31-5 3-carboxy-5-methoxycarbonyl-2,6-dimethyl-4-(o-difluoromethoxyphenyl)-pyridine 
• 97744-34-8 4-(2-Difluoromethoxy-phenyl)-2-methyl-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-3-carboxylic acid methyl ester 

Relevant articles and documents

Preparation and properties of ryodipine, an effective antihypertensive agent

A novel effective antihypertensive agent, 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydro pyridine (ryodipine, PP-1466) has been obtained. A method for ryosidine synthesis has been developed, and by products of PP-1466 synthesis have been isolated and identified. Special characteristics (IRS, UVS, NMR, MS) and chromatography data (TLC, HPLC) are cited.