N-Sulfinyl-p-toluidine

Base Information

• Chemical Name: N-Sulfinyl-p-toluidine
• CAS No.: 15795-42-3
• Molecular Formula: C7H7 N O S
• Molecular Weight: 153.205
• Hs Code.: 2930909090
• Mol file: 15795-42-3.mol

Synonyms:p-Toluidine,N-sulfinyl- (6CI,7CI,8CI); 4-Methyl-N-sulfinylaniline;4-Methyl-N-sulfinylbenzenamine; N-Sulfinyl-4-methylbenzenamine;N-Sulfinyl-p-toluidine; N-p-Tolylsulfinylamine; NSC 77661; Thionyl-p-toluidine;p-Methyl-N-sulfinylaniline; p-Tolylsulfinylamine

Chemical Property of N-Sulfinyl-p-toluidine

Chemical Property:

• Vapor Pressure: 0.101mmHg at 25°C
• Boiling Point: 230.3°Cat760mmHg
• Flash Point: 93.1°C
• PSA: 61.52000
• Density: 1.15g/cm³
• LogP: 2.88880

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Sulfinyl-p-toluidine

There total 12 articles about N-Sulfinyl-p-toluidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(chlorosulfinyl)imidazole (76541-52-1) + p-toluidine (106-49-0,12221-03-3) → N-sulfinyl-4-methylaniline (15795-42-3)

Guidance literature:

In dichloromethane; 1.)-40 deg C 2.)20 deg C, 0.5 h;

DOI:10.1016/S0040-4039(00)89260-6

Reference yield: 84.0%

p-toluidine (106-49-0,12221-03-3) → N-sulfinyl-4-methylaniline (15795-42-3)

Guidance literature:

With thionyl chloride; In toluene; at 20 ℃; for 16h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201409969

Reference yield: 72.0%

p-toluidine (106-49-0,12221-03-3) + N,N'-Thionyldiimidazole (3005-50-3) → N-sulfinyl-4-methylaniline (15795-42-3)

Guidance literature:

In dichloromethane; 1.) -40 deg C, 2.) 20 deg C, 25 min;

DOI:10.1016/S0040-4039(00)89260-6

upstream raw materials:

p-toluidine hydrochloride

p-toluidine

1,1,1-trimethyl-N-(4-methylphenyl)silanamine

N-(chlorosulfinyl)imidazole

Downstream raw materials:

4-Methylazobenzol

N,N'-Di-o-tolyl-diazene N-oxide

p-tolyl-amidosulfuric acid ; compound with 4-methylaniline

1,2-di(p-tolyl)diazene

Refernces

• 1、 Veremeichik,Merabov,Chuiko,Lodochnikova,Plemenkov. "Synthesis of benzo-ortho-thiazines S-oxides by diels-alder reaction of N-sulfinylanilines with norbornadiene". . p. 1605 - 1609. Retrieved 2014/02/14.
• 2、 Jian, Teng-Yue,He, Lin,Tang, Cen,Ye, Song. "N-heterocyclic carbene catalysis: Enantioselective formal [2+2] cycloaddition of ketenes and N-sulfinylanilines". supporting information; body text. p. 9104 - 9107. Retrieved 2011/10/13.