7-Hydroxy-2,3-dimethylchromone

Base Information

• Chemical Name: 7-Hydroxy-2,3-dimethylchromone
• CAS No.: 2569-75-7
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.199
• DSSTox Substance ID: DTXSID70180388
• Wikidata: Q83050920
• Mol file: 2569-75-7.mol

Synonyms:7-Hydroxy-2,3-dimethylchromone;2569-75-7;Chromone, 7-hydroxy-2,3-dimethyl-;7-hydroxy-2,3-dimethylchromen-4-one;SCHEMBL3956317;DTXSID70180388;UZYVCVUBLCTORQ-UHFFFAOYSA-N;7-hydroxy-2,3-dimethyl-4H-chromen-4-one

Chemical Property of 7-Hydroxy-2,3-dimethylchromone

Chemical Property:

• Vapor Pressure: 2.47E-05mmHg at 25°C
• Boiling Point: 348.6°Cat760mmHg
• Flash Point: 140.4°C
• PSA: 50.44000
• Density: 1.255g/cm³
• LogP: 2.11540
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 190.062994177
• Heavy Atom Count: 14
• Complexity: 293

Purity/Quality:

99% ^*data from raw suppliers

7-hydroxy-2,3-dimethyl-4H-chromen-4-one 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(OC2=C(C1=O)C=CC(=C2)O)C

Technology Process of 7-Hydroxy-2,3-dimethylchromone

There total 11 articles about 7-Hydroxy-2,3-dimethylchromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2',4'-dihydroxypropiophenone (5792-36-9) + acetic anhydride (108-24-7) → 7-Hydroxy-2,3-dimethylchromone (2569-75-7)

Guidance literature:

2',4'-dihydroxypropiophenone; acetic anhydride; With sodium acetate; for 3h; Heating;

With triethylamine; Heating;

With hydrogenchloride; for 4h;

DOI:10.1016/j.farmac.2004.08.004

Reference yield: 76.0%

2,3-dimethyl-7-acetoxychromone (17584-92-8) → 7-Hydroxy-2,3-dimethylchromone (2569-75-7)

Guidance literature:

With sodium hydrogencarbonate; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jm0400505

Reference yield: 46.0%

2',4'-dihydroxypropiophenone (5792-36-9) + 2-[4-(dimethylamino)phenyl]acetic acid (17078-28-3) + acetic anhydride (108-24-7) → 7-Hydroxy-2,3-dimethylchromone (2569-75-7) + 3-(4-dimethylamino-phenyl)-4-ethyl-7-hydroxy-chromen-2-one

Guidance literature:

2',4'-dihydroxypropiophenone; 2-[4-(dimethylamino)phenyl]acetic acid; acetic anhydride; With triethylamine; for 23h; Heating;

With sulfuric acid; In ethanol; for 4h; Heating;

DOI:10.1016/j.farmac.2004.08.004

upstream raw materials:

2,3-dimethyl-7-acetoxychromone

1-(2,4-diacetoxyphenyl)propane-1-one

2',4'-dihydroxypropiophenone

acetic anhydride

Downstream raw materials:

8-benzoyl-7-hydroxy-2,3-dimethyl-chromen-4-one

(2,3-dimethyl-4-oxo-4H-chromen-7-yloxy)-acetic acid ethyl ester

7,8-Dihydroxy-2,3-dimethyl-chromon

7-(2,3-difluorophenyl)-2,3-dimethyl-4H-chromone