2-[(3-Methylphenyl)amino]acetohydrazide

Base Information

• Chemical Name: 2-[(3-Methylphenyl)amino]acetohydrazide
• CAS No.: 2371-35-9
• Molecular Formula: C9H13N3O
• Molecular Weight: 179.222
• Hs Code.: 2928000090
• NSC Number: 190356
• DSSTox Substance ID: DTXSID40307202
• Wikidata: Q82054571
• Mol file: 2371-35-9.mol

Synonyms:2-[(3-methylphenyl)amino]acetohydrazide;2371-35-9;2-(3-methylanilino)acetohydrazide;2-(m-Tolylamino)acetohydrazide;m-Tolylamino-acetic acid hydrazide;m-Tolylaminoacetic acid hydrazide;NSC190356;Glycine, N-(3-methylphenyl)-, hydrazide;Oprea1_663845;Oprea1_770610;SCHEMBL21642918;DTXSID40307202;MFCD02255619;STK070482;AKOS000321662;NSC-190356;SB86175;LS-01398;BB 0240608;CS-0320635;A918640;2-[(3-methylphenyl)amino]acetohydrazide (non-preferred name)

Chemical Property of 2-[(3-Methylphenyl)amino]acetohydrazide

Chemical Property:

• Vapor Pressure: 5.72E-08mmHg at 25°C
• Refractive Index: 1.61
• Boiling Point: 440.8 °C at 760 mmHg
• PKA: 12.83±0.37(Predicted)
• Flash Point: 220.4 °C
• PSA: 67.15000
• Density: 1.184 g/cm³
• LogP: 1.56100
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 179.105862047
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

98%min ^*data from raw suppliers

2-[(3-Methylphenyl)amino]acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC=C1)NCC(=O)NN

Technology Process of 2-[(3-Methylphenyl)amino]acetohydrazide

There total 4 articles about 2-[(3-Methylphenyl)amino]acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-(m-tolylamino)acetate (126689-79-0) → 2-(m-tolylamino)acetohydrazide (2371-35-9)

Guidance literature:

With hydrazine hydrate;

DOI:10.1002/cmdc.201200407

Reference yield: 90.0%

N-(3-methylphenyl)glycine ethyl ester (21911-66-0) → 2-(m-tolylamino)acetohydrazide (2371-35-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 16h; Reflux;

Reference yield:

1-amino-3-methylbenzene (108-44-1) → 2-(m-tolylamino)acetohydrazide (2371-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 110 °C

2: hydrazine hydrate / ethanol / 16 h / Reflux

With hydrazine hydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-(m-tolylamino)acetate

1-amino-3-methylbenzene

N-(3-methylphenyl)glycine ethyl ester

Refernces

• 1、 Schrader, Florian C.,Glinca, Serghei,Sattler, Julia M.,Dahse, Hans-Martin,Afanador, Gustavo A.,Prigge, Sean T.,Lanzer, Michael,Mueller, Ann-Kristin,Klebe, Gerhard,Schlitzer, Martin. "Novel TypeII Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents". . p. 442 - 461. Retrieved 2013/08/25.