[3-(4-chlorophenyl)-3-hydroxy-2,3-dihydro[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid

Base Information

• Chemical Name: [3-(4-chlorophenyl)-3-hydroxy-2,3-dihydro[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid
• CAS No.: 39225-26-8
• Molecular Formula: C17H13ClN2O3S
• Molecular Weight: 360.8147
• Mol file: 39225-26-8.mol

Synonyms:[3-(4-chloro-phenyl)-3-hydroxy-2,3-dihydro-benzo[4,5]imidazo[2,1-b]thiazol-2-yl]-acetic acid;3-(p-Chlorophenyl)-2,3-dihydro-3-hydroxythiazolo[3,2-a]-benzimidazole-2-acetic acid;

Chemical Property of [3-(4-chlorophenyl)-3-hydroxy-2,3-dihydro[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid

Chemical Property:

• Vapor Pressure: 4.11E-18mmHg at 25°C
• Boiling Point: 656.2°C at 760 mmHg
• Flash Point: 350.6°C
• PSA: 100.65000
• Density: 1.57g/cm³
• LogP: 3.33210

Purity/Quality:

99% ^*data from raw suppliers

WY-13876 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [3-(4-chlorophenyl)-3-hydroxy-2,3-dihydro[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid

There total 4 articles about [3-(4-chlorophenyl)-3-hydroxy-2,3-dihydro[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[3-(4-chloro-phenyl)-3-hydroxy-2,3-dihydro-benzo[4,5]imidazo[2,1-b]thiazol-2-yl]-acetic acid ethyl ester (39225-25-7) → 3-(p-Chlorophenyl)-2,3-dihydro-3-hydroxy-thiazolo[3,2-a]-benzimidazole-2-acetic acid (39225-26-8)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/jm00226a016

Reference yield:

ethyl 3-(benzimidazol-2-ylthio)-3-(p-chlorobenzoyl)propionate hydrobromide (39225-24-6) → 3-(p-Chlorophenyl)-2,3-dihydro-3-hydroxy-thiazolo[3,2-a]-benzimidazole-2-acetic acid (39225-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O

2: aq. NaOH

With sodium hydroxide; water;

DOI:10.1021/jm00226a016

Reference yield:

3-bromo-3-(4-chlorobenzoyl)propionic acid (35158-39-5) + Benzimidazol-2-thiol (134469-07-1) → 3-(p-Chlorophenyl)-2,3-dihydro-3-hydroxy-thiazolo[3,2-a]-benzimidazole-2-acetic acid (39225-26-8)

Guidance literature:

In acetic acid;

DOI:10.1021/jm00226a016

upstream raw materials:

3-bromo-3-(4-chlorobenzoyl)propionic acid

Benzimidazol-2-thiol

[3-(4-chloro-phenyl)-3-hydroxy-2,3-dihydro-benzo[4,5]imidazo[2,1-b]thiazol-2-yl]-acetic acid ethyl ester

ethyl 3-(benzimidazol-2-ylthio)-3-(p-chlorobenzoyl)propionate hydrobromide

Downstream raw materials:

2-(4-chloro-benzoyl)-2,3-dihydro-benzo[4,5]imidazo[2,1-b][1,3]thiazin-4-one

3-(p-chlorophenyl)-thiazolo[3,2-a]benzimidazole-2-acetic acid

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