1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione

Base Information

Chemical Name:1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione
CAS No.:6296-05-5
Molecular Formula:C14H11NO3
Molecular Weight:241.246
Hs Code.:
NSC Number:49654
DSSTox Substance ID:DTXSID30287201
Wikidata:Q82023157

Synonyms:6296-05-5;1-(2-hydroxyphenyl)-3-pyridin-4-ylpropane-1,3-dione;1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione;NSC49654;SCHEMBL12904305;DTXSID30287201;NSC-49654

Suppliers and Price of 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione

Chemical Property:

Vapor Pressure:1.1E-08mmHg at 25°C
Boiling Point:449.1°Cat760mmHg
Flash Point:225.4°C
Density:1.279g/cm³
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:241.07389321
Heavy Atom Count:18
Complexity:310

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)CC(=O)C2=CC=NC=C2)O

Technology Process of 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione

There total 6 articles about 1-(2-Hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 93717-62-5
2-acetylphenyl isonicotinate

: 6296-05-5
1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione

Guidance literature:: With potassium hydroxide; In pyridine; at 100 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/jm200818j

Reference yield:

: 1570-45-2
isonicotinic acid ethylester

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 6296-05-5
1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 1 - 5 ℃; for 3h;

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 6296-05-5
1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 0 - 20 °C

2: KOH / pyridine / 40 °C

With pyridine; potassium hydroxide; In pyridine; 2: mixed-Claisen rearrangement;
DOI:10.1016/S0968-0896(03)00435-8