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1570-45-2

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1570-45-2 Usage

Chemical Properties

clear colorless to light brown liquid

Uses

Ethyl isonicotinate is an organic building block, used in the synthesis of various pharmaceutical and biologically active compounds. It is also a pyridine compound that is shown to be able to trap the thrips in the corp.

Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic fumes of NOx.

Check Digit Verification of cas no

The CAS Registry Mumber 1570-45-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,7 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1570-45:
(6*1)+(5*5)+(4*7)+(3*0)+(2*4)+(1*5)=72
72 % 10 = 2
So 1570-45-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO2/c1-2-11-8(10)7-3-5-9-6-4-7/h3-6H,2H2,1H3

1570-45-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • Alfa Aesar

  • (L03010)  Ethyl isonicotinate, 98%   

  • 1570-45-2

  • 100g

  • 572.0CNY

  • Detail
  • Alfa Aesar

  • (L03010)  Ethyl isonicotinate, 98%   

  • 1570-45-2

  • 500g

  • 2290.0CNY

  • Detail
  • Aldrich

  • (104736)  Ethylisonicotinate  98%

  • 1570-45-2

  • 104736-100G

  • 683.28CNY

  • Detail
  • Aldrich

  • (104736)  Ethylisonicotinate  98%

  • 1570-45-2

  • 104736-500G

  • 2,809.17CNY

  • Detail
  • Aldrich

  • (104736)  Ethylisonicotinate  98%

  • 1570-45-2

  • 104736-100G

  • 683.28CNY

  • Detail
  • Aldrich

  • (104736)  Ethylisonicotinate  98%

  • 1570-45-2

  • 104736-500G

  • 2,809.17CNY

  • Detail
  • Aldrich

  • (104736)  Ethylisonicotinate  98%

  • 1570-45-2

  • 104736-100G

  • 683.28CNY

  • Detail
  • Aldrich

  • (104736)  Ethylisonicotinate  98%

  • 1570-45-2

  • 104736-500G

  • 2,809.17CNY

  • Detail
  • Aldrich

  • (104736)  Ethylisonicotinate  98%

  • 1570-45-2

  • 104736-100G

  • 683.28CNY

  • Detail
  • Aldrich

  • (104736)  Ethylisonicotinate  98%

  • 1570-45-2

  • 104736-500G

  • 2,809.17CNY

  • Detail

1570-45-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl isonicotinate

1.2 Other means of identification

Product number -
Other names 4-Pyridinecarboxylic acid, ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1570-45-2 SDS

1570-45-2Relevant articles and documents

Synthesis, characterization, antioxidant activities, and DNA-binding studies of (E)-N′-[1-(pyridin-2-yl)ethylidene]isonicotinohydrazide and its Pr(III) and Nd(III) complexes

Hao, Zhong-Yan,Liu, Qi-Wan,Xu, Jun,Jia, Lei,Li, Shao-Bai

, p. 1306 - 1312 (2010)

A new ligand, (E)-N′-[1-(pyridin-2-yl)ethylidene]isonicotinohydrazide (HL), was prepared by condensation of 2-acetylpyridine and isonicotinohydrazide in ethanol. Its two lanthanide(III) complexes, [NdIII(L) 2(NO3)(CH3OH)2]?CH 3CH2OH (1), and [PrIII(L)2(NO 3)(CH3OH)2]?CH3CH 2OH (2), have been synthesized and characterized on the basis of element analyses, molar conductivities and IR spectra. The structure of complex 2 has been confirmed by X-ray diffraction. In addition, the DNA-binding properties of the two complexes have been investigated by electronic absorption spectroscopy, fluorescence spectroscopy, circular dichroic (CD) spectroscopy and viscosity measurements. The experimental results suggest that the two complexes bind to DNA via a groove binding mode, and the binding affinity of complex 2 is higher than that of complex 1. Furthermore, the antioxidant activities (superoxide and hydroxyl radical) of the ligand and its metal complexes were determined by spectrophotometry methods in vitro. These complexes were found to possess potent antioxidant activity and be superior to standard antioxidant like mannitol.

Transition metal complexes of N′-(2-(hydroxyimino)propanoyl)isonicotinohydrazide: Synthesis, characterization, DNA interaction and anticancer evaluation

Hegde, Divya,Naik, Ganesh N.,Vadavi, Ramesh S.,Shyam Kumar,Barretto, Delicia A.,Gudasi, Kalagouda B.

, p. 301 - 315 (2017)

A new tetradentate chelating ligand, N′-(2-(hydroxyimino)propanoyl)isonicotinohydrazide and its selective transition metal complexes have been synthesized and evaluated for anticancer behavior. The ligand structure was determined by single-crystal X-ray crystallography. All complexes were investigated by elemental, thermogravimetric analysis, IR, NMR, ESI Mass and electronic spectroscopic studies. The ligand exhibited monoclinic lattice structure with Cc space group, having 4 ligand molecules in each unit cell. The geometrical isomerism (E and Z) was observed in ligand due to the restricted rotation along the >C[dbnd]N– functional group. The interaction of ligand and complexes with calf-thymus DNA (CT-DNA) has been extensively studied using absorption, emission, viscosity and thermal denaturation studies with E. coli DNA. The DNA cleavage properties were screened using plasmid pBR322 DNA by gel electrophoresis method. Complexes have been evaluated for their in vitro antiproliferative activity against human cancer cells of different origin such as MCF-7, Mia-Pa-Ca-2 and DU-145 by using SRB (sulforhodamine B) assay, in which iron complex have shown better antiproliferative activity compared to remaining complexes.

Development of a Novel Chemoenzymatic Process for (S)-1-(Pyridin-4-yl)-1,3-propanediol

Chen, Shao-Xin,Peng, Peng,Tang, Jia-Wei,Wang, Hong-Yi,Yan, Hai-Jun,Zhang, Fu-Li

, p. 2890 - 2897 (2020)

We first developed a novel and efficient chemoenzymatic process to prepare (S)-1-(pyridin-4-yl)-1,3-propanediol, a vital HepDirect prodrug intermediate, from inexpensive and commercially available isonicotinic acid. Through this process, we provide a creative way to obtain the key chiral intermediate, β-hydroxyester, with ketoreductase (KRED) EA. After optimization of the process, we performed the reaction on a 100 g scale with a substrate concentration of up to 150 g/L, a yield of 93%, and an ee value of up to 99.9%. Additionally, we used a simple and effective NaBH4/MgCl2 reduction system to obtain (S)-1-(pyridin-4-yl)-1,3-propanediol with >99.9% ee and an 80% yield. This novel chemoenzymatic process has the potential to be a cost-effective and environmentally friendly process suitable for industrial use.

Pleuromutilin derivative with 1, 3, 4-oxadiazole side chain and preparation and application thereof

-

Paragraph 0055-0056; 0070; 0090; 0092; 0095; 0102, (2021/07/24)

The invention belongs to the field of medicinal chemistry, and particularly relates to a pleuromutilin derivative with a 1, 3, 4-oxadiazole side chain and preparation and application thereof The pleuromutilin derivative with the 1, 3, 4-oxadiazole side chain is a compound shown in a formula 2 or a pharmaceutically acceptable salt thereof, and a solvent compound, an enantiomer, a diastereoisomer and a tautomer of the compound shown in the formula 2 or the pharmaceutically acceptable salt thereof or a mixture of the solvent compound, the enantiomer, the diastereoisomer and the tautomer in any proportion, including a racemic mixture. The pleuromutilin derivative has good antibacterial activity, is especially suitable for being used as a novel antibacterial agent for systemic system infection of animals or human beings, and has good water solubility.

Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and in Vivo Studies

Jung, Sascha,Fuchs, Natalie,Johe, Patrick,Wagner, Annika,Diehl, Erika,Yuliani, Tri,Zimmer, Collin,Barthels, Fabian,Zimmermann, Robert A.,Klein, Philipp,Waigel, Waldemar,Meyr, Jessica,Opatz, Till,Tenzer, Stefan,Distler, Ute,R?der, Hans-Joachim,Kersten, Christian,Engels, Bernd,Hellmich, Ute A.,Klein, Jochen,Schirmeister, Tanja

, p. 12322 - 12358 (2021/09/02)

Rhodesain is a major cysteine protease of Trypanosoma brucei rhodesiense, a pathogen causing Human African Trypanosomiasis, and a validated drug target. Recently, we reported the development of α-halovinylsulfones as a new class of covalent reversible cysteine protease inhibitors. Here, α-fluorovinylsulfones/-sulfonates were optimized for rhodesain based on molecular modeling approaches. 2d, the most potent and selective inhibitor in the series, shows a single-digit nanomolar affinity and high selectivity toward mammalian cathepsins B and L. Enzymatic dilution assays and MS experiments indicate that 2d is a slow-tight binder (Ki = 3 nM). Furthermore, the nonfluorinated 2d-(H) shows favorable metabolism and biodistribution by accumulation in mice brain tissue after intraperitoneal and oral administration. The highest antitrypanosomal activity was observed for inhibitors with an N-terminal 2,3-dihydrobenzo[b][1,4]dioxine group and a 4-Me-Phe residue in P2 (2e/4e) with nanomolar EC50 values (0.14/0.80 μM). The different mechanisms of reversible and irreversible inhibitors were explained using QM/MM calculations and MD simulations.

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