5-Nitro-2-phenoxyaniline

Base Information

• Chemical Name: 5-Nitro-2-phenoxyaniline
• CAS No.: 5410-98-0
• Molecular Formula: C12H10N2O3
• Molecular Weight: 230.223
• NSC Number: 10866
• DSSTox Substance ID: DTXSID50278974
• Wikidata: Q82011209
• Mol file: 5410-98-0.mol

Synonyms:5-nitro-2-phenoxyaniline;5410-98-0;5-nitro-2-phenoxy-aniline;NSC10866;5-nitro-2-phenoxyphenylamine;2-amino-4 -nitrodiphenyl ether;DTXSID50278974;NSC 10866;NSC-10866;AKOS011797771;A833671

Chemical Property of 5-Nitro-2-phenoxyaniline

Chemical Property:

• Vapor Pressure: 1.45E-05mmHg at 25°C
• Boiling Point: 366.6°Cat760mmHg
• Flash Point: 175.5°C
• Density: 1.322g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 230.06914219
• Heavy Atom Count: 17
• Complexity: 261

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=C(C=C(C=C2)[N+](=O)[O-])N

Technology Process of 5-Nitro-2-phenoxyaniline

There total 3 articles about 5-Nitro-2-phenoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-formamido-4-nitrodiphenyl ester → 5-nitro-2-phenoxy-aniline (5410-98-0)

Guidance literature:

With polyphosphiric acid; trichlorophosphate; at 120 - 130 ℃; for 2h;

DOI:10.1007/BF02464359

Reference yield: 0.5%

2,4-dinitrophenyl phenyl ether (2486-07-9) → 5-nitro-2-phenoxy-aniline (5410-98-0) + (2,4-dinitro-phenyl)-hydrazine (119-26-6)

Guidance literature:

With nickel; hydrazine hydrate; In ethanol; 1,2-dichloro-ethane; at 50 - 60 ℃; for 3h;

DOI:10.1246/bcsj.56.3159

Reference yield:

→ 5-nitro-2-phenoxy-aniline (5410-98-0)

Guidance literature:

/BRN= 2845813/;

DOI:10.1039/jr9570000295

upstream raw materials:

2,4-dinitrophenyl phenyl ether

Downstream raw materials:

2-iodo-4-nitro-1-phenoxybenzene

1-Benzoyl-3-(5-nitro-2-phenoxy-phenyl)-thiourea

3-iodo-4-phenoxy-aniline

(2,4-diiodo-phenyl)-phenyl ether