diazo-2

Base Information

Chemical Name:diazo-2
CAS No.:124029-65-8
Molecular Formula:C25H26 N4 O11
Molecular Weight:558.49414
Hs Code.:
Mol file:124029-65-8.mol

Synonyms:Glycine,N-[2-[2-[2-[bis(carboxymethyl)amino]-5-(diazoacetyl)phenoxy]ethoxy]-4-methylphenyl]-N-(carboxymethyl)-(9CI); Diazo 2

Suppliers and Price of diazo-2

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of diazo-2

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：225.35000
Density:g/cm³
LogP:0.77878

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of diazo-2

There total 12 articles about diazo-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 124029-65-8
{[2-{2-[2-(Bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-4-(2-diazo-acetyl)-phenyl]-carboxymethyl-amino}-acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) pyridine; 2.) H₂O / 1.) 100 deg C, 30 min

2: SOCl₂, DMF / 0.25 h / Heating

3: pyridine / CHCl₃ / Heating

4: 45percent aq. KOH / methanol / 0.5 h

5: 92 percent / K₂CO₃, N-methylpyrrolidinone / 0.17 h / 140 °C

6: 81 percent / H₂ / 5percent Pd/C / ethyl acetate; ethanol / 1 h / Ambient temperature

7: 78 percent / 1,8-bis(dimethylamino)naphthalene / 48 h / 125 °C

8: CF₃COOH / CH₂Cl₂ / Ambient temperature

9: oxalyl chloride / CH₂Cl₂ / 0.17 h / Heating

10: 46 percent / ethanol; CH₂Cl₂ / Ambient temperature

11: 1M aq. tetramethylammonium hydroxide / methanol / Ambient temperature

With pyridine; 1-methyl-pyrrolidin-2-one; potassium hydroxide; thionyl chloride; oxalyl dichloride; tetramethyl ammoniumhydroxide; water; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; ethyl acetate;
DOI:10.1021/ja00202a042

Reference yield:

: 51257-24-0
3-Acetoxy-4-Nitrobenzoic Acid

: 124029-65-8
{[2-{2-[2-(Bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-4-(2-diazo-acetyl)-phenyl]-carboxymethyl-amino}-acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1: SOCl₂, DMF / 0.25 h / Heating

2: pyridine / CHCl₃ / Heating

3: 45percent aq. KOH / methanol / 0.5 h

4: 92 percent / K₂CO₃, N-methylpyrrolidinone / 0.17 h / 140 °C

5: 81 percent / H₂ / 5percent Pd/C / ethyl acetate; ethanol / 1 h / Ambient temperature

6: 78 percent / 1,8-bis(dimethylamino)naphthalene / 48 h / 125 °C

7: CF₃COOH / CH₂Cl₂ / Ambient temperature

8: oxalyl chloride / CH₂Cl₂ / 0.17 h / Heating

9: 46 percent / ethanol; CH₂Cl₂ / Ambient temperature

10: 1M aq. tetramethylammonium hydroxide / methanol / Ambient temperature

With pyridine; 1-methyl-pyrrolidin-2-one; potassium hydroxide; thionyl chloride; oxalyl dichloride; tetramethyl ammoniumhydroxide; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; ethyl acetate;
DOI:10.1021/ja00202a042

Reference yield:

: 96315-07-0
1-bromo-2-(2'-nitro-5'-methylphenoxy)ethane

: 124029-65-8
{[2-{2-[2-(Bis-carboxymethyl-amino)-5-methyl-phenoxy]-ethoxy}-4-(2-diazo-acetyl)-phenyl]-carboxymethyl-amino}-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / K₂CO₃, N-methylpyrrolidinone / 0.17 h / 140 °C

2: 81 percent / H₂ / 5percent Pd/C / ethyl acetate; ethanol / 1 h / Ambient temperature

3: 78 percent / 1,8-bis(dimethylamino)naphthalene / 48 h / 125 °C

4: CF₃COOH / CH₂Cl₂ / Ambient temperature

5: oxalyl chloride / CH₂Cl₂ / 0.17 h / Heating

6: 46 percent / ethanol; CH₂Cl₂ / Ambient temperature

7: 1M aq. tetramethylammonium hydroxide / methanol / Ambient temperature

With 1-methyl-pyrrolidin-2-one; oxalyl dichloride; tetramethyl ammoniumhydroxide; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/ja00202a042