619-14-7

Basic information

• Product Name: 3-Hydroxy-4-nitrobenzoic acid
• Synonyms: 3-HYDROXY-4-NITROBENZOIC ACID;3-HYDROXYL-4-NITROBENZOIC ACID;4-NITRO-3-HYDROXYBENZOIC ACID;RARECHEM AL BE 0673;Benzoic acid, 3-hydroxy-4-nitro-;3-Hydroxyl-4-nitrobenzoic;3-HYDROXY-4-NITROBENZOIC ACID 99%;3-Hydroxy-4-nitrobenzoic acid,98%
• CAS NO: 619-14-7
• Molecular Formula: C7H5NO5
• Molecular Weight: 183.12
• EINECS: 210-580-9
• Product Categories: Benzene derivatives;FINE Chemical & INTERMEDIATES;blocks;Carboxes;NitroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic Acids;Phenyls & Phenyl-Het;Carboxylic Acids;Phenyls & Phenyl-Het;C7;Carbonyl Compounds
• Mol File: 619-14-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 229-231 °C(lit.)
• Boiling Point: 316.77°C (rough estimate)
• Flash Point: 175.4 °C
• Appearance: Yellow to brown/Powder
• Density: 1.6074 (rough estimate)
• Vapor Pressure: 1.74E-06mmHg at 25°C
• Refractive Index: 1.6280 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 1.08g/l (calculated)
• PKA: 3.30±0.10(Predicted)
• Water Solubility: insoluble
• BRN: 2107564
• CAS DataBase Reference: 3-Hydroxy-4-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-4-nitrobenzoic acid(619-14-7)
• EPA Substance Registry System: 3-Hydroxy-4-nitrobenzoic acid(619-14-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 619-14-7(Hazardous Substances Data)

Usage

Uses

3-Hydroxy-4-nitrobenzoic acid is a compound that is capable of inhibiting chloroplast development in linseed and oat seedlings. 3-Hydroxy-4-nitrobenzoic acid also exhibits inhibitory effects on Ras proteins, making them potentially useful compounds in treating cancer.

InChI:InChI=1/C7H5NO5/c9-6-3-4(7(10)11)1-2-5(6)8(12)13/h1-3,9H,(H,10,11)/p-2

Upstream product

• 700-38-9 2-nitro-5-methylphenol 
• 99-06-9 3-Carboxyphenol 
• 6968-22-5 3-amino-4-nitrobenzoic acid 
• 2374-03-0 4-aminosalicylic acid 
• 1357303-91-3 3-(2-methylhexanoyloxy)-4-nitrobenzoic acid 
• 1357303-90-2 3-(2-bromohexanoyloxy)-4-nitrobenzoic acid 
• 121-92-6 3-nitrobenzoic acid 
• 90729-86-5 3-hydroxy-4-nitrocinnamic acid 
• 704-13-2 5-formyl-2-nitrophenol 
• 7697-37-2 nitric acid 
• 7732-18-5 water 
• 98-95-3 nitrobenzene 
• 85724-92-1 3-(dodecanoyloxy)-4-nitrobenzoic acid 
• 115162-24-8 4-nitro-3-(undecanoyloxy)benzoic acid 

Downstream Products

• 875846-16-5 3-propyloxy-4-nitrobenzoic acid 
• 55894-52-5 4-nitro-3-(octanoyloxy)-benzoic acid 
• 115162-20-4 4-nitro-3-<<4'-nitro-3'-(octanoyloxy)benzoyl>oxy>-benzoic acid 
• 115162-24-8 4-nitro-3-(undecanoyloxy)benzoic acid 
• 55894-53-6 3-(decanoyloxy)-4-nitrobenzoic acid 
• 115162-21-5 3-(butyryloxy)-4-nitrobenzoic acid 
• 36852-58-1 3-Hydroxy-4-nitro-benzoylchlorid 
• 51257-24-0 3-Acetoxy-4-Nitrobenzoic Acid 
• 61161-83-9 5-(hydroxymethyl)-2-nitrophenol 
• 1280220-20-3 2-(3-hydroxy-4-nitrophenyl)benzothiazole 
• 1357303-91-3 3-(2-methylhexanoyloxy)-4-nitrobenzoic acid 
• 66630-74-8 4-amino-3-(methylamino)benzoic acid 
• 1325676-63-8 4-amino-N-methyl-3-methylamino-benzamide 
• 1390657-80-3 (3-hydroxy-4-nitrophenyl)(pyrrolidin-1-yl)methanone 

Relevant articles and documents

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Evaluation of snake venom phospholipase A2: Hydrolysis of non-natural esters

Phospholipase A2 from the rattlesnake Crotalus durissus terrificus was employed for the first time to test its enantioseletivity on the hydrolysis of different non-natural esters. It was observed that the structure of this small enzyme is restrictive in the choice of its lipase action with non-natural substrates. Two forms of the enzyme were used; free and as its cross-linked enzyme aggregate (CLEA). With all substrates, the free enzyme showed activity similar to the CLEA preparation. The advantage of the CLEA phospholipase is the possibility to reuse it in several consecutive reactions without a decrease of activity and selectivity with good but higher yields and ee than with the free enzyme.

Nitrophenol derivatives oxidized by cerium(IV) ammonium nitrate (CAN) and their cytotoxicity

Oxidation of a series of phenols with cerium(IV) ammonium nitrate (CAN) in acetonitrile undermild conditions yields the mixture of corresponding nitrophenols. In the cases of methylphenols and hydroxy-carboxylic acids, the steric effect may reduce the nitration reaction. Compounds 3 a and 4b showed selective activities to Hep 3B and Hep G2 cancer cell lines, respectively. Compound 2c showed selective activities to Hep G2 and MDA-MB-231 cancer cell lines. Further more, com pound 10b showed selective activities to Hep G2, Hep 3B, MCF-7 and MDA-MB-231 cancer cell lines.