1-(2,4-Dimethoxy-3-methylphenyl)ethanone

Base Information

• Chemical Name: 1-(2,4-Dimethoxy-3-methylphenyl)ethanone
• CAS No.: 60512-80-3
• Molecular Formula: C11H14 O3
• Molecular Weight: 194.23
• Hs Code.: 2914509090
• NSC Number: 156899
• DSSTox Substance ID: DTXSID10303130
• Nikkaji Number: J2.232.374A
• Wikidata: Q82048268
• Mol file: 60512-80-3.mol

Synonyms:1-(2,4-Dimethoxy-3-methylphenyl)ethanone;60512-80-3;2',4'-Dimethoxy-3'-methylacetophenone;1-(2,4-DIMETHOXY-3-METHYL-PHENYL)-ETHANONE;NSC156899;SCHEMBL5144939;DTXSID10303130;Acetophenone,4'-dimethoxy-3'-methyl-;AKOS006275704;NSC-156899;Acetophenone, 2',4'-dimethoxy-3'-methyl-;A8442;FT-0718497;1-(2,4-Dimethoxy-3-methylphenyl)ethanone #;2',4'-DIMETHOXY-3'-METHYL-ACETOPHENONE;InChI=1/C11H14O3/c1-7-10(13-3)6-5-9(8(2)12)11(7)14-4/h5-6H,1-4H

Chemical Property of 1-(2,4-Dimethoxy-3-methylphenyl)ethanone

Chemical Property:

• Vapor Pressure: 0.000556mmHg at 25°C
• Boiling Point: 311.7°C at 760 mmHg
• Flash Point: 133.2°C
• PSA: 35.53000
• Density: 1.048g/cm³
• LogP: 2.21480
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

97% ^*data from raw suppliers

2',4'-DIMETHOXY-3'-METHYL-ACETOPHENONE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1OC)C(=O)C)OC

Technology Process of 1-(2,4-Dimethoxy-3-methylphenyl)ethanone

There total 7 articles about 1-(2,4-Dimethoxy-3-methylphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-dimethoxytoluene (5673-07-4) + acetyl chloride (75-36-5) → 2′,4′-dimethoxy-3′-methylacetophenone (60512-80-3)

Guidance literature:

acetyl chloride; With titanium tetrachloride; at 0 ℃; for 0.25h;

2,6-dimethoxytoluene; In benzene; for 0.5h;

DOI:10.1515/znb-2003-0413

Reference yield: 95.0%

2,6-dimethoxytoluene (5673-07-4) → 2′,4′-dimethoxy-3′-methylacetophenone (60512-80-3)

Guidance literature:

acetyl chloride; With titanium tetrachloride; at -10 ℃; for 0.1h;

2,6-dimethoxytoluene; In benzene; at -10 - 0 ℃; for 0.666667h;

Reference yield: 95.0%

1-(2-hydroxy-4-methoxy-3-methylphenyl)ethanone (69469-91-6) + dimethyl sulfate (77-78-1) → 2′,4′-dimethoxy-3′-methylacetophenone (60512-80-3)

Guidance literature:

With potassium carbonate; In acetone; for 48h;

DOI:10.1055/s-2002-33919

upstream raw materials:

2,6-dimethoxytoluene

acetyl chloride

1-(2-hydroxy-4-methoxy-3-methylphenyl)ethanone

dimethyl sulfate

Downstream raw materials:

3-(2',4'-dimethoxy-3'-methylphenyl)-1-methylpropane-1,3-dione

acetic acid 2,4-dimethoxy-3-methyl-phenyl ester

2,4-dimethoxy-3-methylphenol

2-methoxy-3-methyl-1,4-benzoquinone