1-(4-CHLORO-PHENYL)-PYRROLIDINE

Base Information

• Chemical Name: 1-(4-CHLORO-PHENYL)-PYRROLIDINE
• CAS No.: 4280-30-2
• Molecular Formula: C10H12ClN
• Molecular Weight: 181.665
• Hs Code.: 2933990090
• Mol file: 4280-30-2.mol

Synonyms:1-(4-Chlor-phenyl)-pyrrolidin;N-(4-chlorophenyl)-pyrrolidine;1-(4-Chlorophenyl)-Pyrrolidine;1-p-(4-chlorophenyl)pyrrolidine;Pyrrolidine,1-(4-chlorophenyl);

Chemical Property of 1-(4-CHLORO-PHENYL)-PYRROLIDINE

Chemical Property:

• Vapor Pressure: 0.00235mmHg at 25°C
• Boiling Point: 288.4°Cat760mmHg
• Flash Point: 128.2°C
• PSA: 3.24000
• Density: 1.165g/cm³
• LogP: 3.00520

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-CHLORO-PHENYL)-PYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-CHLORO-PHENYL)-PYRROLIDINE

There total 19 articles about 1-(4-CHLORO-PHENYL)-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyrrolidine (123-75-1) + bromochlorobenzene (106-39-8) → 1-(4-chlorophenyl)pyrrolidine (4280-30-2)

Guidance literature:

With copper(l) iodide; dimethylaminoacetic acid; tetra(n-butyl)phosphonium malonate; In dimethyl sulfoxide; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.200903158

Reference yield: 95.0%

1-(4-chlorophenyl)pyrrolidine-2,5-dione (6943-00-6) → 1-(4-chlorophenyl)pyrrolidine (4280-30-2)

Guidance literature:

With diborane;

DOI:10.1021/jo00164a023

Reference yield: 93.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + N-ethyl-4-chloro-aniline (13519-75-0) → 1-(4-chlorophenyl)pyrrolidine (4280-30-2)

Guidance literature:

With titanium tetrachloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; o-xylene; at 120 ℃; for 14h; Sealed tube;

DOI:10.1039/d0ob00880j

upstream raw materials:

4-chloro-aniline

1,4-dichlorobutane

1-(4-chlorophenyl)pyrrolidine-2,5-dione

1,4-dibromo-butane

Downstream raw materials:

5-chloro-2-(1-pyrrolidinyl)nitrobenzene

Refernces

• 1、 Katsurayama, Yoshino,Ikabata, Yasuhiro,Maeda, Hajime,Segi, Masahito,Nakai, Hiromi,Furuyama, Taniyuki. "Direct Near Infrared Light–Activatable Phthalocyanine Catalysts". supporting information. . Retrieved 2021/12/22.
• 2、 Yi, Ming-Jun,Xiao, Teng-Fei,Li, Wen-Hui,Zhang, Yi-Fan,Yan, Pen-Ji,Zhang, Baoxin,Xu, Peng-Fei,Xu, Guo-Qiang. "Organic photoredox catalytic α-C(sp3)-H phosphorylation of saturated: Aza -heterocycles". supporting information. p. 13158 - 13161. Retrieved 2021/12/16.