METHYL(2E,4S)-(-)-4-(PHENYLMETHOXY)PENT-2-ENOATE

Base Information

• Chemical Name: METHYL(2E,4S)-(-)-4-(PHENYLMETHOXY)PENT-2-ENOATE
• CAS No.: 112489-57-3
• Molecular Formula: C13H16 O3
• Molecular Weight: 220.268
• Hs Code.: 29189990
• Mol file: 112489-57-3.mol

Synonyms:2-Pentenoicacid, 4-(phenylmethoxy)-, methyl ester, [S-(E)]-; Methyl(-)-(2E,4S)-4-(phenylmethoxy)pent-2-enoate

Chemical Property of METHYL(2E,4S)-(-)-4-(PHENYLMETHOXY)PENT-2-ENOATE

Chemical Property:

• Vapor Pressure: 0.000552mmHg at 25°C
• Boiling Point: 311.8°Cat760mmHg
• Flash Point: 127.5°C
• PSA: 35.53000
• Density: 1.055g/cm³
• LogP: 2.32090
• Storage Temp.: Refrigerator (+4°C)

Purity/Quality:

98%min ^*data from raw suppliers

(S,E)-(-)-METHYL-4-(PHENYLMETHOXY)PENT-2-ENOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL(2E,4S)-(-)-4-(PHENYLMETHOXY)PENT-2-ENOATE

There total 11 articles about METHYL(2E,4S)-(-)-4-(PHENYLMETHOXY)PENT-2-ENOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Methyl diethylphosphonoacetate (1067-74-9) + (S)-2-(benzyloxy)propanal (81445-44-5) → (E)-(S)-[MeCH(OCH2C6H5)CHCHCO2Me] (112489-57-3)

Guidance literature:

With triethylamine; lithium bromide; In acetonitrile; at 0 - 20 ℃; for 12h;

DOI:10.1016/S0022-328X(96)06850-7

Reference yield: 84.0%

bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate (88738-78-7) + (S)-2-(benzyloxy)propanal (81445-44-5) → methyl (Z)-(S)-4-phenylmethoxy-2-pentenoate (112489-56-2) + (E)-(S)-[MeCH(OCH2C6H5)CHCHCO2Me] (112489-57-3)

Guidance literature:

With potassium hydride; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1016/S0040-4020(01)86823-X

Reference yield:

(S)-2-(benzyloxy)propanal (81445-44-5) + (methoxycarbonylmethylene)tri-n-butylphosphorane (108269-37-0) → methyl (Z)-(S)-4-phenylmethoxy-2-pentenoate (112489-56-2) + (E)-(S)-[MeCH(OCH2C6H5)CHCHCO2Me] (112489-57-3)

Guidance literature:

With benzoic acid; In toluene; at 90 ℃; for 0.166667h; Title compound not separated from byproducts.;

DOI:10.1021/ol016729+

upstream raw materials:

(S)-2-(benzyloxy)propanal

methyl (triphenylphosphoranylidene)acetate

trimethyl phosphonoacetate

bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate

Downstream raw materials:

<2-(R),3-(R),3'-(S),4-(R),5-(S)>-3-(1,4-dioxaspiro<4.5>dec-2-yl)-2,4-dicarbomethoxy-5-phenylpyrrolidine

2,4-dicarbomethoxy-3-(1-phenylmethoxyethyl)-5-phenylpyrrolidine

2,4-dicarbomethoxy-3-(1-phenylmethoxyethyl)-5-phenylpyrrolidine

2,4-dicarbomethoxy-3-(1-phenylmethoxyethyl)-5-(4-methoxyphenyl)pyrrolidine