bis(4-chlorophenyl)(pyrimidin-5-yl)methanol

Base Information

• Chemical Name: bis(4-chlorophenyl)(pyrimidin-5-yl)methanol
• CAS No.: 26766-35-8
• Molecular Formula: C17H12 Cl2 N2 O
• Molecular Weight: 331.201
• Mol file: 26766-35-8.mol

Synonyms:5-Pyrimidinemethanol,a,a-bis(p-chlorophenyl)- (8CI); LY 43578; NSC 626916; a,a-Bis(4-chlorophenyl)-5-pyrimidinemethanol

Chemical Property of bis(4-chlorophenyl)(pyrimidin-5-yl)methanol

Chemical Property:

• Vapor Pressure: 1.31E-10mmHg at 25°C
• Boiling Point: 494.9°Cat760mmHg
• Flash Point: 253.1°C
• Density: 1.376g/cm³

Purity/Quality:

>98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of bis(4-chlorophenyl)(pyrimidin-5-yl)methanol

There total 1 articles about bis(4-chlorophenyl)(pyrimidin-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

5-bromopyrimidine (4595-59-9) + 4,4'-Dichlorobenzophenone (90-98-2) → α,α-bis(4-chlorophenyl)-5-pyrimidinemethanol (26766-35-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -95 - 20 ℃;

DOI:10.1021/jm00391a016

Reference yield: 72.0%

α,α-bis(4-chlorophenyl)-5-pyrimidinemethanol (26766-35-8) → 5--pyrimidine (108394-99-6)

Guidance literature:

With thionyl chloride; In dichloromethane; for 4h;

DOI:10.1021/jm00391a016

Reference yield: 55.0%

α,α-bis(4-chlorophenyl)-5-pyrimidinemethanol (26766-35-8) → α,α-bis(4-chlorophenyl)-5-methylpyrimidine (26766-37-0)

Guidance literature:

With hydrogenchloride; acetic acid; tin(ll) chloride; at 20 ℃; Reflux;

DOI:10.1021/jm2015809

upstream raw materials:

5-bromopyrimidine

4,4'-Dichlorobenzophenone

Downstream raw materials:

α,α-bis(4-chlorophenyl)-5-methylpyrimidine

5--1,4,5,6-tetrahydropyrimidine

5--1,6-dihydropyrimidine

5--pyrimidine