3,4,5-Trimethoxybenzohydrazide

Base Information

• Chemical Name: 3,4,5-Trimethoxybenzohydrazide
• CAS No.: 3291-03-0
• Molecular Formula: C10H14N2O4
• Molecular Weight: 226.232
• Hs Code.: 2928000090
• European Community (EC) Number: 221-954-6
• NSC Number: 39075
• UNII: EY296A96YG
• DSSTox Substance ID: DTXSID00186570
• Nikkaji Number: J86.131F
• Wikidata: Q72513697
• Mol file: 3291-03-0.mol

Synonyms:3,4,5-Trimethoxybenzohydrazide;3291-03-0;3,4,5-Trimethoxybenzhydrazide;3,4,5-Trimethoxybenzoic acid hydrazide;3,4,5-Trimethoxybenzoic hydrazide;NSC39075;EY296A96YG;EINECS 221-954-6;NSC-39075;3,4,5-Trimethoxybenzene-1-carbohydrazide;Benzoic acid, 3,4,5-trimethoxy-, hydrazide;3,4,5-trimethoxybenzoylhydrazine;3,4,5triMeOPhCO;Maybridge1_004292;UNII-EY296A96YG;Oprea1_589557;Oprea1_782539;SCHEMBL2451128;HMS553L04;DTXSID00186570;3,4,5-Trimethoxybenzohydrazide #;Benzhydrazide, 3,4,5-trimethoxy-;Benzohydrazide, 3,4,5-trimethoxy-;BBL036121;MFCD00014758;NSC 39075;STK090115;AKOS000194933;3,4,5-trimethoxy-benzoic acid hydrazide;3,4,5-Trimethoxybenzoic acid, hydrazide;3,4,5-TRIMETHOXYBENZOYLHYDRAZIDE;MS-10966;(3,4,5-TRIMETHOXYBENZOYL)HYDRAZINE;FT-0614160;EN300-17240;A51172;A875483;W-106805;Z56899164;F1099-0057

Chemical Property of 3,4,5-Trimethoxybenzohydrazide

Chemical Property:

• Melting Point: 158-160 °C
• Refractive Index: 1.534
• PKA: 11.78±0.10(Predicted)
• PSA: 82.81000
• Density: 1.197 g/cm³
• LogP: 1.40710
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 226.09535693
• Heavy Atom Count: 16
• Complexity: 223

Purity/Quality:

97% ^*data from raw suppliers

3,4,5-Trimethoxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C(=O)NN
• Uses: 3,4,5-Trimethoxybenzohydrazide is used in preparation of compounds having photochromic and fluorescent properties and application thereof.

Technology Process of 3,4,5-Trimethoxybenzohydrazide

There total 9 articles about 3,4,5-Trimethoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0) → 3,4,5-trimethoxybenzohydrazide (3291-03-0)

Guidance literature:

With hydrazine; at 92 ℃; for 4h;

Reference yield: 95.0%

Eudesmic acid (118-41-2) → 3,4,5-trimethoxybenzohydrazide (3291-03-0)

Guidance literature:

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; at 5 - 20 ℃; Reagent/catalyst; Temperature;

DOI:10.13005/ojc/330126

Reference yield: 92.0%

3,4,5-trimethoxybenzoyl bromide → 3,4,5-trimethoxybenzohydrazide (3291-03-0)

Guidance literature:

With hydrazine; In acetonitrile; at 20 ℃; for 0.25h;

DOI:10.3390/ph13110393

upstream raw materials:

ethyl 3,4,5-trimethoxybenzoate

3,4,5-trimethoxybenzoic acid methyl ester

3,4,5-Trimethoxybenzoyl chloride

Eudesmic acid

Downstream raw materials:

3,4,5-trimethoxy-benzoic acid (3,4,5-trimethoxy-benzylidene)-hydrazide

Eudesmic acid

N-benzenesulfonyl-N'-(3,4,5-trimethoxy-benzoyl)-hydrazine

N-(tolul-4-sulfonyl)-N'-(3,4,5-trimethoxy-benzoyl)-hydrazine