118-41-2

Basic information

• Product Name: Gallic acid trimethyl ether
• Synonyms: 3,4,5-TRIMETHOXYBENZOIC ACID / GALLIC ACID TRIMETHYL ETHER;Gallic acid trimethyl ether, Trimethylgallic acid;5-TriMethoxybenzoic acid;3,4,5-TriMethoxybenzoic acid, 99% 100GR;3,4,5-TriMethoxybenzoic acid, 99% 5GR;NSC 2525;3,4,5-TRIMETHOXYBENZOIC ACID FOR SYNTHES;3,4,5-TriMethoxybenzoic acid ReagentPlus(R), 99%
• CAS NO: 118-41-2
• Molecular Formula: C₁₀H₁₂O₅
• Molecular Weight: 212.2
• EINECS: 204-248-2
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;Aromatics;Metabolites & Impurities;carboxylic acid;Aromatics, Metabolites & Impurities;Pyridines
• Mol File: 118-41-2.mol
• Article Data: 172

Chemical Properties

• Melting Point: 168-171 °C(lit.)
• Boiling Point: 225-227 °C10 mm Hg(lit.)
• Flash Point: 225-226°C/10mm
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.3006 (rough estimate)
• Vapor Pressure: 2.49E-06mmHg at 25°C
• Refractive Index: 1.5140 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.23±0.10(Predicted)
• Water Solubility: SLIGHTLY SOLUBLE
• BRN: 884655
• CAS DataBase Reference: Gallic acid trimethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: Gallic acid trimethyl ether(118-41-2)
• EPA Substance Registry System: Gallic acid trimethyl ether(118-41-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• WGK Germany: 1
• TSCA: Yes
• Hazardous Substances Data: 118-41-2(Hazardous Substances Data)

Usage

Description

3,4,5-Trimethoxybenzoic acid is an important fine chemical product or pharmaceutical intermediate, which is widely used in the fields of medicine, dye, food and fine chemical industry.

Synthesis

3,4,5-trimethoxybenzoic acid can be synthesised by methoxylation of gallic acid and dimethyl sulfate, and the fine product is obtained after neutralization, filtration and washing.

Physical properties

3,4,5-Trimethoxy benzoic acid is a white to beige fine crystalline powder.

Uses

A metabolite of Trimebutine (T795605).

Uses

3,4,5-Trimethoxybenzoic acid is used as intermediates in medicine and organic synthesis. It acts as a metabolite of trimebutine. It is widely used in making dyes and inks, photographic developers and used as astringents in medically.

Definition

ChEBI: A benzoic acid derivative carrying 3-, 4- and 5-methoxy substituents.

InChI:InChI=1/C10H12O5/c1-13-7-4-6(10(11)12)5-8(14-2)9(7)15-3/h4-5H,1-3H3,(H,11,12)/p-1

Synthetic route

3,4,5-trimethoxy-benzaldehyde (86-81-7) → Eudesmic acid (118-41-2)

Conditions	Yield
With copper acetylacetonate; oxygen; sodium hydroxide; 1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene In water at 50℃; under 760.051 Torr; for 12h; Sealed tube;	99%
With tert.-butylhydroperoxide In water at 70℃; for 3h; Green chemistry;	91%
With sodium chlorite In acetonitrile 1.) 10 deg C, 2 h, 2.) RT, 3 h;	90%

(3,4,5-trimethoxyphenyl)methanol (3840-31-1) → Eudesmic acid (118-41-2)

Conditions	Yield
With dihydrogen peroxide In water; toluene at 20 - 85℃; for 4h;	99%
With Cu(II)-complex of salen-H4; dihydrogen peroxide In acetonitrile at 80℃; for 2h;	93%
With dihydrogen peroxide; oxygen; (2-OPhCH2NHCH2)2(2-)*Co(2+) In acetonitrile at 80℃; for 4h;	80%
Stage #1: (3,4,5-trimethoxyphenyl)methanol With C27H29BrFIrN2O; potassium hydroxide In toluene for 4h; Inert atmosphere; Reflux; Stage #2: With hydrogenchloride In water	72%

C19H32O5Si → Eudesmic acid (118-41-2)

Conditions	Yield
With water; N,N-dimethyl-formamide at 70℃; for 6h; Green chemistry; chemoselective reaction;	96%

tert-butylisonitrile (119072-55-8, 7188-38-7) + 3,4,5-trimethoxyphenylboronic Acid (182163-96-8) → Eudesmic acid (118-41-2)

Conditions	Yield
Stage #1: tert-butylisonitrile; 3,4,5-trimethoxyphenylboronic Acid With copper diacetate; palladium diacetate In N,N-dimethyl-formamide at 100℃; for 24h; Molecular sieve; Sealed tube; Stage #2: With water In N,N-dimethyl-formamide Molecular sieve; Sealed tube;	96%

3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0) → Eudesmic acid (118-41-2)

Conditions	Yield
Stage #1: 3,4,5-trimethoxybenzoic acid methyl ester With potassium hydroxide In ethanol; water for 3h; Reflux; Stage #2: With sulfuric acid In water	95%
With potassium hydroxide In ethanol for 48h; Reflux;	95.6%
With potassium hydroxide In ethanol for 48h; Reflux;	95.6%

3,4,5-trihydroxybenzoic acid (149-91-7) + carbonic acid dimethyl ester (616-38-6) → Eudesmic acid (118-41-2)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 120℃; Concentration; Inert atmosphere;	95.6%

methyl (3,4,5-trimethoxyphenyl) ketone (1136-86-3) → Eudesmic acid (118-41-2)

Conditions	Yield
With Oxone; trifluoroacetic acid In 1,4-dioxane for 10h; Reflux; Green chemistry;	95%
With Iron(III) nitrate nonahydrate; iodine; oxygen; dimethyl sulfoxide at 130℃; under 750.075 Torr; for 12h; Sealed tube; Green chemistry;	81%
With Iron(III) nitrate nonahydrate; iodine; oxygen In dimethyl sulfoxide at 10℃; for 12h; Sealed tube;	81%
With water; potassium hydroxide at 20℃; Electrolysis;

C26H30O5Si → Eudesmic acid (118-41-2)

Conditions	Yield
With water; N,N-dimethyl-formamide at 70℃; for 6h; Green chemistry; chemoselective reaction;	95%

carbon monoxide (201230-82-2) + 3,4,5-trimethoxyphenyl trifluoromethanesulfonate (143287-98-3) → Eudesmic acid (118-41-2)

Conditions	Yield
With potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate In dimethyl sulfoxide at 60℃; for 3h;	94%

3,4,5-trimethoxybenzaldehyde oxime (39201-89-3) → Eudesmic acid (118-41-2)

Conditions	Yield
With [hydroxy(tosyloxy)iodo]benzene; water In dimethyl sulfoxide at 20℃; for 24h;	92%
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 50h; Heating;	16%

acetic acid 3,4,5-trimethoxy-phenyl ester (17742-46-0) → Eudesmic acid (118-41-2)

Conditions	Yield
With boron trifluoride diethyl etherate; acetic acid at 70℃; for 4h;	91%

2-(3,4,5-trimethoxyphenyl)-2-oxoacetaldehyde (150114-69-5) → Eudesmic acid (118-41-2)

Conditions	Yield
With iodine; dimethyl sulfoxide at 180℃; for 0.0833333h; Inert atmosphere; Microwave irradiation;	89%

C18H20O6S → Eudesmic acid (118-41-2)

Conditions	Yield
With ammonium cerium (IV) nitrate; oxygen In acetonitrile at 20 - 50℃; for 4h;	88%

3,4,5-trimethoxybenzylamine (18638-99-8) → Eudesmic acid (118-41-2)

Conditions	Yield
With tert.-butylhydroperoxide at 120℃; for 5h; Ionic liquid;	86%

3,4,5-trihydroxybenzoic acid (149-91-7) + dimethyl sulfate (77-78-1) → Eudesmic acid (118-41-2)

Conditions	Yield
	85%
cetyltrimethylammonim bromide In sodium hydroxide; chloroform Ambient temperature;	80%
With tetra-(n-butyl)ammonium iodide; potassium carbonate for 12h; Reflux;	78%

3,4,5-trimethoxy-benzoic acid tert-butyl ester (211429-78-6) → Eudesmic acid (118-41-2)

Conditions	Yield
With water; iodine In acetonitrile for 3h; Heating;	82%

2-bromo-3,4,5-trimethoxybenzoic acid (23346-82-9) → 3,4,5-trimethoxy-2-(2-oxopropyl)benzoic acid (75322-69-9) + Eudesmic acid (118-41-2)

Conditions	Yield
With acetone for 2h;	A 77% B 11%

tert.-butylhydroperoxide (75-91-2) + (3,4,5-trimethoxyphenyl)methanol (3840-31-1) → 3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0) + Eudesmic acid (118-41-2)

Conditions	Yield
With potassium phosphate; copper quinolate; tetra-(n-butyl)ammonium iodide In water; dimethyl sulfoxide at 120℃; for 24h;	A 70% B n/a

4-methyl-N′-(3,4,5-trimethoxybenzylidene)-benzenesulfonohydrazide (188493-61-0) → Eudesmic acid (118-41-2)

Conditions	Yield
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 20h; Heating;	68%

2-(3,4,5-trimethoxyphenyl)acetonitrile (13338-63-1) → Eudesmic acid (118-41-2)

Conditions	Yield
With tert.-butylhydroperoxide; copper diacetate In neat (no solvent) at 80℃; for 5h; Green chemistry;	68%

1-(3,4,5-trimethoxyhenyl)ethanol (36266-40-7) → Eudesmic acid (118-41-2)

Conditions	Yield
With Iron(III) nitrate nonahydrate; iodine; oxygen; dimethyl sulfoxide at 130℃; under 750.075 Torr; for 12h; Sealed tube; Green chemistry;	68%
With Iron(III) nitrate nonahydrate; iodine; oxygen In dimethyl sulfoxide at 110℃; for 12h; Sealed tube;	68%

C20H23NO4 (1207605-84-2) → C6H4NCH2CHCCH2 (491-35-0) + C20H22N2O5 (1370460-33-5) + Eudesmic acid (118-41-2)

Conditions	Yield
With trifluoroacetic acid; sodium nitrite In chloroform at 0 - 5℃; for 1h;	A n/a B 46% C n/a

4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyramide (88775-41-1) → 1-(benzo[d][1,3]dioxol-6-yl)ethanone (3162-29-6) + (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (88775-49-9) + 4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyric acid (88775-29-5) + Eudesmic acid (118-41-2)

Conditions	Yield
With sodium hydroxide In ethanol for 10h; Product distribution; Heating; var. condition;	A 16% B 18.5% C 44.7% D 13.6%
With sodium hydroxide In ethanol for 10h; Heating;	A 0.227 g B n/a C n/a D n/a
With sodium hydroxide In ethanol for 6h; Heating;	A 0.021 g B 0.056 g C 0.14 g D 0.023 g

Iron(III) nitrate nonahydrate + cobalt(II) nitrate hexahydrate + methyl (3,4,5-trimethoxyphenyl) ketone (1136-86-3) → Eudesmic acid (118-41-2)

Conditions	Yield
	41%

3,4,5-trimethoxybenzaldehyde N-[-(3,4,5-trimethoxyphenyl)methylidene]hydrazone (7251-01-6) → Eudesmic acid (118-41-2)

Conditions	Yield
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 40h; Heating;	33%

diazomethane (186581-53-3, 908094-01-9) + 3,4,5-triacetoxybenzoic acid (6635-24-1) → Eudesmic acid (118-41-2)

Conditions	Yield
With piperidine; ethanol anschliessendes Erwaermen mit wss. Alkalilauge;

mescaline (54-04-6) → Eudesmic acid (118-41-2)

Conditions	Yield
With potassium permanganate

3,4,5-trimethoxycinnamic acid (90-50-6) → Eudesmic acid (118-41-2)

Conditions	Yield
With alkaline permanganate at 60 - 65℃;

3,4,5-trimethoxytoluene (6443-69-2) → Eudesmic acid (118-41-2)

Conditions	Yield
With potassium permanganate

methanol (67-56-1) + Eudesmic acid (118-41-2) → 3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0)

Conditions	Yield
With sulfuric acid at 65℃; for 24h;	100%
at 65℃; for 24h; Acidic conditions;	100%
With sulfuric acid Reflux;	97%

Eudesmic acid (118-41-2) → 3,4,5-Trimethoxybenzoyl chloride (4521-61-3)

Conditions	Yield
With thionyl chloride In dichloromethane Heating;	100%
With thionyl chloride In chloroform for 4h; Reflux;	100%
With thionyl chloride In CH2C3 for 3h; Reflux;	100%

Eudesmic acid (118-41-2) → (2-bromo-3,4,5-trimethoxyphenyl)methanol (73252-54-7)

Conditions	Yield
With sodium tetrahydroborate; zirconium(IV) chloride In tetrahydrofuran for 12h;	100%

13(S)-labdan-8α,15-diol (10267-21-7) + Eudesmic acid (118-41-2) → 13(S)-labdan-8α-ol-15-yl 3,4,5-trimethoxybenzoate

Conditions	Yield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; Cooling with ice;	100%

6-chloro-1-hexanol (2009-83-8) + Eudesmic acid (118-41-2) → 6-chlorohexyl 3,4,5-trimethoxybenzoate

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 49h; Inert atmosphere;	100%

Eudesmic acid (118-41-2) → 2-iodo-3,4,5-trimethoxybenzoic acid (98799-41-8)

Conditions	Yield
With iodine; silver trifluoroacetate In chloroform for 3h;	99%
With iodine; silver trifluoroacetate In chloroform at 65℃; for 4.5h; Inert atmosphere;	93%
With mercury(II) diacetate; sodium chloride 2.) ethanol, reflux, 25 min; Yield given. Multistep reaction;

anthracene-9-carboxylic acid 3-(3-hydroxypropylmethylamino)propyl ester + Eudesmic acid (118-41-2) → anthracene-9-carboxylic acid 3-{methyl-[3-(3,4,5-trimethoxy-benzoyloxy)-propyl]-amino}-propyl ester

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 73h;	99%

(tetrabutylammonium)2(octa-μ3-bromo-hexafluoro-octahedro-hexamolybdate) + Eudesmic acid (118-41-2) → ((nBu)4N)2[Mo6Br8(OOCC6H2(OCH3)3)6]

Conditions	Yield
In tetrahydrofuran byproducts: HF; react. of Mo complex with 6 equiv. of HOOCC6H2(OCH3)3 at heating; detd. by IR, (1)H and (13)F NMR spectroscopy;	99%

ethanol (64-17-5) + Eudesmic acid (118-41-2) → ethyl 3,4,5-trimethoxybenzoate (6178-44-5)

Conditions	Yield
With sulfuric acid for 3h; Heating;	98%
With sulfuric acid Reflux;	91%
With sulfuric acid	81%

Triethyl orthoacetate (78-39-7) + Eudesmic acid (118-41-2) → ethyl 3,4,5-trimethoxybenzoate (6178-44-5)

Conditions	Yield
In various solvent(s) at 80℃; for 4.5h;	98%

O-methylresorcine (150-19-6) + Eudesmic acid (118-41-2) → 3-methoxyphenyl 3,4,5-trimethoxybenzoate (55744-83-7)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h;	98%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + Eudesmic acid (118-41-2) → N-methoxy-N-methyl-3,4,5-trimethoxybenzamide (118779-14-9)

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; Inert atmosphere;	98%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 3h;	82%
In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;

4,4'-dimethoxydiphenylacetylene (2132-62-9) + Eudesmic acid (118-41-2) → 5,6,7-trimethoxy-3,4-bis(4-methoxyphenyl)isocoumarin (1431884-36-4)

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate In N,N-dimethyl-formamide at 120℃; for 6h; regioselective reaction;	98%

2-(4-bromo-7-methoxybenzo[d][1,3]dioxol-5-yl)ethan-1-amine (1238432-32-0) + Eudesmic acid (118-41-2) → N-(2-(4-bromo-7-methoxybenzo[d][1,3]dioxol-5-yl)ethyl)-3,4,5-trimethoxybenzamide

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h;	98%

(R)-3-bromo-2-methyl-1-propanol (93381-28-3) + Eudesmic acid (118-41-2) → (R)-3-bromo-2-methylpropyl 3,4,5-trimethoxybenzoate

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 19h;	98%

3,4-dimethoxyphenol (2033-89-8) + Eudesmic acid (118-41-2) → 3,4-dimethoxyphenyl 3,4,5-trimethoxybenzoate (953387-96-7)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h;	97%

propargyl bromide (106-96-7) + Eudesmic acid (118-41-2) → prop-2-yn-1-yl-3,4,5-trimethoxybenzoate

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 4.5h;	97%

allyl bromide (106-95-6) + Eudesmic acid (118-41-2) → prop-2-en-1-yl-3,4,5-trimethoxybenzoate

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 4.5h;	97%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 50℃; for 18h; Inert atmosphere;

tert-butylisonitrile (119072-55-8, 7188-38-7) + 4-[2,2-bis(trimethylsilyl)ethenyl]benzaldehyde (1268519-27-2) + Eudesmic acid (118-41-2) → (tert-butylcarbamoyl)(4-(2,2-bis(trimethylsilyl)vinyl)phenyl)methyl 3,4,5-trimethoxybenzoate

Conditions	Yield
In water at 20℃; for 2h; Passerini Condensation;	97%

1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) + Eudesmic acid (118-41-2) → C20H21NO5

Conditions	Yield
With [RhCl2(p-cymene)]2; tricyclohexylphosphine oxide; sodium hydrogencarbonate In 1,2-dichloro-ethane at 100℃; for 4h; Sealed tube; regioselective reaction;	97%

N-methylmaleimide (930-88-1) + Eudesmic acid (118-41-2) → 1-methyl-3-(2,3,4-trimethoxyphenyl)pyrrolidine-2,5-dione

Conditions	Yield
With [Ru(O2CMes)2(p-cymene)] In 1,2-dichloro-ethane at 110℃; for 24h; Inert atmosphere; chemoselective reaction;	97%

Eudesmic acid (118-41-2) → 3,4,5-trimethoxybenzoic anhydride (1719-88-6)

Conditions	Yield
With triethylamine; Phenyl N-phenylphosphoramidochloridate In dichloromethane for 1h; Ambient temperature;	96%
With 1-ethyl-piperidine; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride In acetone at 20℃; for 0.5h;	95%
With methanesulfonyl chloride; triethylamine In tetrahydrofuran at 0℃;	90%
With pyridine; thionyl chloride; diethyl ether at 0℃;
With 2,4,6-trimethyl-pyridine; carbon tetrabromide In N,N-dimethyl-formamide for 0.5h; UV-irradiation;	65 %Spectr.

Eudesmic acid (118-41-2) → 2-bromo-3,4,5-trimethoxybenzoic acid (23346-82-9)

Conditions	Yield
With bromine In chloroform; water for 18h; Heating;	96%
With sodium hydroxide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione at 20℃; for 36h;	96%
With bromine In chloroform; water Reflux;	96%

2,3,4-tri-O-acetyl-β-D-glucopyranosylamine uronic acid methyl ester (14365-73-2) + Eudesmic acid (118-41-2) → (2S,3S,4S,5R,6R)-3,4,5-Triacetoxy-6-(3,4,5-trimethoxy-benzoylamino)-tetrahydro-pyran-2-carboxylic acid methyl ester (500340-03-4)

Conditions	Yield
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 12h;	96%

(S)-(-)-4-(3,4,5-trimethoxyphenyl)-3-butyn-2-ol (865266-07-5) + Eudesmic acid (118-41-2) → (2S)-(+)-4-(3,4,5-trimethoxyphenyl)-3-butyn-2-yl 3,4,5-trimethoxybenzoate

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;	96%

1-adamantan-1-yl-3-(3-(4-(piperazin-1-yl)butoxy)phenyl)urea (1254951-29-5) + Eudesmic acid (118-41-2) → 1-adamantan-1-yl-3-(3-(4-(4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl)butoxy)phenyl)urea (1254951-48-8)

Conditions	Yield
Stage #1: 1-adamantan-1-yl-3-(3-(4-(piperazin-1-yl)butoxy)phenyl)urea; Eudesmic acid With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine In dichloromethane for 0.166667h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 10h;	96%
Stage #1: 1-adamantan-1-yl-3-(3-(4-(piperazin-1-yl)butoxy)phenyl)urea With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.166667h; Stage #2: Eudesmic acid With N-ethyl-N,N-diisopropylamine at 0 - 20℃;	69%

1,4-dioxane (123-91-1) + Eudesmic acid (118-41-2) → 1,4-dioxan-2-yl 3,4,5-trimethoxybenzoate (1597710-74-1)

Conditions	Yield
With iron(III)-acetylacetonate; di-tert-butyl peroxide at 120℃; for 24h; Schlenk technique;	96%

Upstream product

• 1401-55-4 Tannic acid 

Downstream Products

• 1916-07-0 Methyl 3,4,5-trimethoxybenzoate 

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