methyl (1S,3R,4S)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclopentane-1-carboxylate

Base Information

• Chemical Name: methyl (1S,3R,4S)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclopentane-1-carboxylate
• CAS No.: 321744-14-3
• Molecular Formula: C₁₂H₂₁NO₅
• Molecular Weight: 259.302
• Hs Code.: 29221985
• DSSTox Substance ID: DTXSID10370347
• Nikkaji Number: J1.479.726B
• Wikidata: Q82157529
• Mol file: 321744-14-3.mol

Synonyms:321744-14-3;methyl (1S,3R,4S)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclopentane-1-carboxylate;(1R,2S,4S)-N-BOC-1-AMINO-2-HYDROXYCYCLOPENTANE-4-CARBOXYLIC ACID METHYL ESTER;methyl (1S,3S,4R)-3-hydroxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopentane-1-carboxylate;(1S,3R,4S)-Methyl 3-((tert-butoxycarbonyl)amino)-4-hydroxycyclopentanecarboxylate;tert-butyl (1R,2S,4S)-4-(methoxycarbonyl)-2-hydroxycyclopentyl-carbamate;SCHEMBL1370105;DTXSID10370347;SSATZBUCOTXXGA-YIZRAAEISA-N;WMA74414;MFCD02259718;AS-73458;CS-0049303;P18722;EN300-7364599;Methyl (1S,3R,4S)-3-(Boc-amino)-4-hydroxycyclopentane-1-carboxylate;Methyl (1S,3R,4S)-3-(Boc-amino)-4-hydroxycyclopentane-1-carboxylate ee;tert-butyl (1R,2S,4S)-4-(methoxycarbonyl)-2-hydroxycyclopentylcarbamate;(1S,3R,4S)-3-tert-Butoxycarbonylamino-4-hydroxycyclopentanecarboxylic acid methyl ester;(1S,3R,4S)-Methyl3-((tert-butoxycarbonyl)amino)-4-hydroxycyclopentanecarboxylate;Methyl (1S,3R,4S)-3-{[(t-butoxy)carbonyl]amino}-4-hydroxycyclopentane-1-carboxylate;n-boc-1(r)-amino-2(s)-hydroxy-cyclopentane-4(s)-carboxylic acid methyl ester;3beta-[(tert-Butyloxycarbonyl)amino]-4beta-hydroxycyclopentane-1beta-carboxylic acid methyl ester;METHYL (1S,3R,4S)-3-{[(TERT-BUTOXY)CARBONYL]AMINO-4-HYDROXYCYCLOPENTANE-1-CARBOXYLATE

Chemical Property of methyl (1S,3R,4S)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclopentane-1-carboxylate

Chemical Property:

• Vapor Pressure: 2.9E-07mmHg at 25°C
• Refractive Index: 1.4596 (estimate)
• Boiling Point: 378°C at 760 mmHg
• Flash Point: 182.4°C
• PSA: 84.86000
• Density: 1.16g/cm³
• LogP: 1.21450
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 259.14197277
• Heavy Atom Count: 18
• Complexity: 323

Purity/Quality:

98.5% ^*data from raw suppliers

(1R,2S,4S)-N-BOC-1-AMINO-2-HYDROXYCYCLOPENTANE-4-CARBOXYLIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1CC(CC1O)C(=O)OC
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H]1C[C@@H](C[C@@H]1O)C(=O)OC

Technology Process of methyl (1S,3R,4S)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclopentane-1-carboxylate

There total 9 articles about methyl (1S,3R,4S)-3-{[(tert-butoxy)carbonyl]amino}-4-hydroxycyclopentane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl chloroformate (79-22-1) + (1S,3R,4S)-3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-hydroxycyclopentanecarboxylic acid (952708-31-5) → (1S,3R,4S)-3-tert-butoxycarbonylamino-4-hydroxycyclopentanecarboxylic acid methyl ester (321744-14-3,321744-18-7)

Guidance literature:

With triethylamine; In methanol; at 5 - 20 ℃; for 18h;

DOI:10.1016/S0957-4166(01)00108-2

Reference yield:

(3R,4S)-4-tert-butoxycarbonylamino-3-hydroxycyclopent-1-enecarboxylic acid methyl ester (329910-42-1) → (1S,3R,4S)-3-tert-butoxycarbonylamino-4-hydroxycyclopentanecarboxylic acid methyl ester (321744-14-3,321744-18-7)

Guidance literature:

With hydrogen; palladium; In methanol;

Reference yield:

(1S,4R)-(-)-methyl-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopent-2-ene-1-carboxylate (168683-02-1) → (1S,3R,4S)-3-tert-butoxycarbonylamino-4-hydroxycyclopentanecarboxylic acid methyl ester (321744-14-3,321744-18-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-bromosuccinimide / tetrahydrofuran; H₂O / 17 h / 20 °C

2.1: KOH / H₂O; methanol / 48 h / 90 °C

2.2: 40 g / tetrahydrofuran; H₂O / 14 h / 20 °C / pH 10.5

3.1: H₂ / Pd/C / methanol / 18 h / 20 °C / 1500.15 Torr

4.1: 59 g / triethylamine / methanol / 5 - 20 °C

With potassium hydroxide; N-Bromosuccinimide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.tet.2003.10.116

upstream raw materials:

methyl chloroformate

(1S,3R,4S)-3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-hydroxycyclopentanecarboxylic acid

(3R,4S)-4-tert-butoxycarbonylamino-3-hydroxycyclopent-1-enecarboxylic acid methyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

(1R,2R,4S)-1-(tert-butoxycarbonylamino)-2-hydroxycyclopentane-4-carboxylic acid methyl ester