168683-02-1

Basic information

• Product Name: 4-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2-CYCLOPENTENE-1-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 4-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2-CYCLOPENTENE-1-CARBOXYLIC ACID METHYL ESTER;(1S,4R)-Methyl 4-((tert-butoxycarbonyl)aMino)cyclopent-2-enecarboxylate;Methyl 4-((tert-butoxycarbonyl)aMino)cyclopent-2-enecarboxylate;PeraMivir InterMediate;Cis-(1S,4R)-4-Boc-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester;methyl(1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate
• CAS NO: 168683-02-1
• Molecular Formula: C₁₂H₁₉NO₄
• Molecular Weight: 241.28
• EINECS: 1308068-626-2
• Mol File: 168683-02-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 331.158ºC at 760 mmHg
• Flash Point: 154.079ºC
• Appearance: /
• Density: 1.11g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: 2-8°C
• PKA: 11.75±0.40(Predicted)
• CAS DataBase Reference: 4-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2-CYCLOPENTENE-1-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2-CYCLOPENTENE-1-CARBOXYLIC ACID METHYL ESTER(168683-02-1)
• EPA Substance Registry System: 4-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2-CYCLOPENTENE-1-CARBOXYLIC ACID METHYL ESTER(168683-02-1)

Safety Data

• Hazardous Substances Data: 168683-02-1(Hazardous Substances Data)

Usage

Uses

(1S,?4R)?-4-?[[(1,?1-?Dimethylethoxy)?carbonyl]?amino]?-2-?cyclopentene-?1-?carboxylic Acid Methyl Ester is an intermediate in the synthesis of Peramivir (P285500).

InChI:InChI=1/C12H19NO4/c1-12(2,3)17-11(15)13-9-6-5-8(7-9)10(14)16-4/h5-6,8-9H,7H2,1-4H3,(H,13,15)/t8-,9+/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 138923-03-2 (1S,4R)-(-)-methyl-4-aminocyclopent-2-en-1-carboxylate hydrochloride 
• 419563-22-7 (1S,4R) methyl 4-aminocyclopent-2-ene-1-carboxylate L-tartrate 
• 34619-03-9 tert-butyldicarbonate 
• 67-56-1 methanol 
• 426226-35-9 (-)-methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate hydrochloride 
• 130931-84-9 (-)-(1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid hydrochloride 
• 49805-30-3 racemic 2-azabicyclo[2.2.1]hept-5-en-3-one 
• 419563-22-7 (1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid methyl ester tartrate 
• 151792-53-9 tert-butyl (1R,4S)-(-)-3-oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate 
• 173464-46-5 (1S,4R)-4-Azido-1-benzoyloxycyclopent-2-ene 
• 173464-48-7 (1S,4R)-1-Benzoyloxy-4-tert-butyloxycarbamoylcyclopent-2-ene 
• 157555-70-9 Benzoic acid (1S,4R)-4-amino-cyclopent-2-enyl ester 
• 4157-02-2 cis 2-cyclopentene 1,4-dibenzoate 

Downstream Products

• 1312161-65-1 C₁₁H₁₇NO₄ 
• 151907-79-8 (1S-cis)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic acid 
• 298716-03-7 (1R,4R)-4-[(tert-butoxycarbonyl)amino]cyclopent-2-ene-1-carboxylic acid 
• 1469338-58-6 (1S,2S,3R,4R)-methyl-3-((S)-1-acetamido-2-ethylbutyl)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)-2-(((3-(((E)-3-(3,4-bis(allyloxy)phenyl)acryloyl)oxy)propyl)carbamoyl)oxy)cyclopentanecarboxylate 

Relevant articles and documents

Facile synthesis of the neuraminidase inhibitor peramivir

An improved and convenient synthetic route for the synthesis of peramivir has been developed with a total 34% yield. The process was improved from previous methods in three key reaction steps including 1,3-dipolar cycloaddition, reductive ring cleavage of

4, 7-DIAZAINDOLE AND 4, 7-DIAZAINDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA

The present invention relates to a compound having the formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing influenza.

5, 7-DIAZAINDOLE AND 5, 7-DIAZAINDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA

The present invention relates to a specific compound having the formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing influenza.

Compound, preparation method thereof and purpose of compound in preparing drug

The invention provides a compound, a preparation method thereof and a purpose of the compound in preparing a drug. The compound is a compound shown in a formula (I) or a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite or a pharmaceutically acceptable salt of the compound shown in the formula (I). The compound provided by the invention can transform peramivir in an injection dosage form into an inhalant dosage form, improves the medication compliance of the peramivir and enables the peramivir to have the characteristics of convenience in use and suitability for use in a wide range; and in addition, the drug directly acts on a respiratory tract and a lung infected with an influenza virus after being inhaled, so that single administration is hopefully realized, and the drug can effectively have double actions of prevention and treatment to the influenza. A chemical formula is described in the description.