2-Hydroxy-5-methylpyridine

Base Information

• Chemical Name: 2-Hydroxy-5-methylpyridine
• CAS No.: 1003-68-5
• Molecular Formula: C6H7NO
• Molecular Weight: 109.128
• Hs Code.: 29333990
• European Community (EC) Number: 213-713-9,618-801-4
• UNII: C173P2D70Y
• DSSTox Substance ID: DTXSID20143120
• Nikkaji Number: J110.369E
• Wikidata: Q27275047
• Mol file: 1003-68-5.mol

Synonyms:5-methyl-2-pyridone

Chemical Property of 2-Hydroxy-5-methylpyridine

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 183-187 °C(lit.)
• Refractive Index: 1.551
• Boiling Point: 304.2 °C at 760 mmHg
• PKA: 12.43±0.10(Predicted)
• Flash Point: 170.6 °C
• PSA: 32.86000
• Density: 1.053 g/cm³
• LogP: 0.68330
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 109.052763847
• Heavy Atom Count: 8
• Complexity: 167

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxy-5-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41-36/37/39
• Safety Statements: 26-36-37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CNC(=O)C=C1
• Uses: 2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides.

Technology Process of 2-Hydroxy-5-methylpyridine

There total 30 articles about 2-Hydroxy-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methoxy-5-methylpyridine hydrohloride → 5-methyl-2-pyridone (1003-68-5)

Guidance literature:

With hydrogenchloride; potassium iodide; In water; at 130 ℃; for 3h; Solvent; Reagent/catalyst; Temperature;

DOI:10.1039/c7gc01740e

Reference yield: 89.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 5-methyl-pyridin-2-ol (1003-68-5,91914-06-6)

Guidance literature:

(5-methyl-pyridin-2-yl)amine; With sulfuric acid; water; sodium nitrite; at 20 ℃; for 6h; Heating / reflux;

With sodium carbonate; In water; at 0 ℃; pH=8;

Reference yield: 81.0%

antimony(V) chloride * 3-methylpyridine N-oxide → 5-methyl-2-pyridone (1003-68-5)

Guidance literature:

In nitromethane; for 10h; Heating;

DOI:10.1016/S0040-4020(01)97935-9

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

6-hydroxy-3-methylpicolinic acid

2-fluoro-5-methylpyridine

3-Methylpyridine

Downstream raw materials:

1,5-dimethylpyridin-2(1H)-one

2-chloro-5-methylpyridine

2-Bromo-5-methylpyridine

5-methyl-2-(trifluoromethanesulfonyl)oxypyridine