2-Bromo-3-(4-methoxyphenyl)acrylic acid

Base Information

• Chemical Name: 2-Bromo-3-(4-methoxyphenyl)acrylic acid
• CAS No.: 90772-66-0
• Molecular Formula: C10H9 Br O3
• Molecular Weight: 257.084
• NSC Number: 409581
• Nikkaji Number: J3.517.124J
• Mol file: 90772-66-0.mol

Synonyms:2-bromo-3-(4-methoxyphenyl)acrylic acid;90772-66-0;2-Propenoicacid, 2-bromo-3-(4-methoxyphenyl)-;NSC409581;AKOS002663224;NSC-409581;J3.517.124J;(Z)-2-Bromo-3-(4-methoxyphenyl)acrylic acid

Chemical Property of 2-Bromo-3-(4-methoxyphenyl)acrylic acid

Chemical Property:

• Vapor Pressure: 2.1E-06mmHg at 25°C
• Boiling Point: 378.5°Cat760mmHg
• Flash Point: 182.7°C
• Density: 1.586g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 255.97351
• Heavy Atom Count: 14
• Complexity: 230

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=C(C(=O)O)Br
• Isomeric SMILES: COC1=CC=C(C=C1)/C=C(/C(=O)O)\Br

Technology Process of 2-Bromo-3-(4-methoxyphenyl)acrylic acid

There total 20 articles about 2-Bromo-3-(4-methoxyphenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(Z)/(E)-ethyl 3-(4-methoxyphenyl)-2-bromo-2-propenoate (871893-64-0) → (Z)-2-bromo-3-(4-methoxyphenyl)acrylic acid (90772-66-0,60451-75-4)

Guidance literature:

With sodium hydroxide; In methanol; dichloromethane; at 5 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol1008813

Reference yield: 74.0%

ethyl 2-bromo-3-(4-methoxyphenyl)-2(Z)-propenoate (123098-26-0) → (Z)-2-bromo-3-(4-methoxyphenyl)acrylic acid (90772-66-0,60451-75-4)

Guidance literature:

With sodium hydroxide; In methanol; dichloromethane; at 20 ℃; for 12h;

DOI:10.1039/c4gc02089h

Reference yield: 19.0%

DL-erythro-α.β-Dibrom-β--propionsaeure-methylester (19308-29-3,19308-35-1,59339-60-5,91089-40-6) → (E)-2-bromo-3-(p-anisyl)propenoic acid (182884-64-6) + (Z)-2-bromo-3-(4-methoxyphenyl)acrylic acid (90772-66-0,60451-75-4)

Guidance literature:

With potassium hydroxide; for 48h; Ambient temperature;

upstream raw materials:

DL-erythro-α.β-Dibrom-β--propionsaeure-methylester

(Z)/(E)-ethyl 3-(4-methoxyphenyl)-2-bromo-2-propenoate

methyl 2-bromo-3-(4-methoxyphenyl)acrylate

ethyl 2-bromo-3-(4-methoxyphenyl)-2(Z)-propenoate

Downstream raw materials:

(Z)-4-(4-methoxybenzylidene)-2-(pyridin-4-yl)-4,5-dihydro-1H-imidazol-5-one

2-phenyl-5-[1-(4-methoxyphenyl)-meth-(Z)-ylidene]-3,5-dihydro-imidazol-4-one

(Z)-4-(4-methoxybenzylidene)-2-propyl-4,5-dihydro-1H-imidazol-5-one

(Z)-2-cyclopropyl-4-(4-methoxybenzylidene)-4,5-dihydro-1H-imidazol-5-one