871893-64-0

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 803-14-5 ethyl 2-bromo-2-(triphenylphosphoranylidene)acetate 
• 124755-24-4 ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate 
• 599-99-5 ethyl tribromoacetate 

Downstream Products

• 51718-85-5 ethyl 3-(4-methoxyphenyl)propynoate 
• 1039341-21-3 (Z)-ethyl 3-(1,3-dioxoisoindolin-2-yl)-3-(4-methoxyphenyl)acrylate 
• 90772-66-0 (Z)-2-bromo-3-(4-methoxyphenyl)acrylic acid 
• 1342341-33-6 (Z)-2-bromo-3-(4-methoxyphenyl)prop-2-en-1-ol 
• 1380159-24-9 (E)-2-bromo-3-(4-methoxyphenyl)prop-2-en-1-ol 

Relevant academic research and scientific papers

A one-pot synthesis of (E)-α-bromo-α,β-unsaturated esters and their trifluoromethylation: A general and stereoselective route to (E)-α-trifluoromethyl-α,β-unsaturated esters

Bromination of a phosphonate anion derived in situ from ethyl bis(2,2,2-trifluoroethyl)phosphonoacetate 3 followed by the addition of aldehydes produced (E)-α-bromo-α,β-unsaturated esters 5 stereoselectively. The treatment of 5 with FSO2CF2CO2Me and CuI in DMF/HMPA provided (E)-α-trifluoromethyl-α,β-unsaturated esters 6.

Preparation of α-bromoacrylates: One-pot procedure for the synthesis of conjugated acetylenic carboxylates from aldehydes with Ph3P/ Br3CCO2Et

We have established the optimal conditions for the Wittig reaction for synthesizing α-bromoacrylates with a high selectivity, and developed a simple and efficient one-pot procedure for preparing various conjugated acetylenic carboxylates in moderate to high yields. Georg Thieme Verlag Stuttgart.

A convenient synthesis and the asymmetric hydrogenation of N-phthaloyl dehydroamino acid esters

(Chemical Equation Presented) A convenient synthetic method was reported for the preparation of N-phthaloyl dehydroamino acid esters from easily accessible vinyl bromides (or vinyl tosylate) and potassium phthalimide. Rh-catalyzed asymmetric hydrogenation

Site-specific preparation of 2-carboalkoxy-4-substituted naphthalenes and 9-alkylphenanthrenes and evidence for an allene intermediate in the novel base-catalyzed cyclization of 2-alkynylbiphenyls

A site-specific preparation of 2-carboalkoxy-4-substituted naphthalenes and 9-alkylphenanthrenes is described. The successful cyclization of an allene intermediate provides supportive evidence for the previously proposed mechanism.

Versatile Transformations of α,β-Dibromoesters and Ketones in Basic Media under Microwave Irradiation

Depending on the reaction medium, α,β-dibromoesters under microwave irradiation may selectively lead to α-bromoalk-enes, to alkenes or to (E)-β-bromostyrenes. The corresponding ketones give selectively the α-bromoketones.

Microwave-assisted tandem nucleophilic substitution-Wittig reaction of α-hypervalent iodine functionalized phosphonium ylide

Under microwave irradiation conditions the tandem nucleophilic substitution-Wittig reaction of α-hypervalent iodine functionalized phosphonium ylide can occur readily to afford α-heteroatom substituted-α,β-unsaturated enoates in good yields stereo-selecti

A new route to α-trifluoromethyl-α,β-unsaturated esters

The treatment of α-bromo-α,β-unsaturated esters with FSO2CF2CO2Me and CuI in DMF/HMPA constitutes a new synthetic scheme for the preparation of α-trifluoromethyl-α,β-unsaturated esters. (C) 2000 Elsevier Science Ltd.

Synthesis of 2′,3′-Dideoxy-2′-trifluoromethylnucleosides from α-Trifluoromethyl-α,β-unsaturated Ester

The treatment of α-bromo-α,β-unsaturated esters 2 with FSO2CF2CO2Me and CuI in DMF/HMPA constitutes a new synthetic scheme for the preparation of α-trifluoromethyl-α,β-unsaturated esters 3. The trifluoromethylation of (Z)/(E)-ethyl 3-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-bromo-2-propenoate (2e), which is derived from 1-(R)-glyceraldehyde acetonide, yields the key intermediate α-trifluoromethyl-αβ-unsaturated esters 3e. This is transformed into anomeric acetates 8a and 8b and is used for the synthesis of a number of 2′,3′-dideoxy-2′-trifluoromethylnucleosides.