Haplafine

Base Information

• Chemical Name: Haplafine
• CAS No.: 54357-78-7
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.27400
• Hs Code.: 2933790090
• Mol file: 54357-78-7.mol

Synonyms:haplaphine;

Chemical Property of Haplafine

Chemical Property:

• PSA: 42.09000
• LogP: 2.87310

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Haplafine

There total 2 articles about Haplafine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.3%

4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3) + prenyl bromide (870-63-3) → 3,3-bis(γ,γ-dimethylallyl)-2.4-dioxo-1,2,3,4-tetrahydroquinoline (21873-59-6) + 4-(3',3'-Dimethylallyloxy)-3-(3'',3''-dimethylallyl)-2-chinolon (18118-29-1) + 4-(3',3'-Dimethylallyloxy)-2-chinolon (54357-78-7) + 3-(1',1'-Dimethylallyl)-4-hydroxy-2-chinolon

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In toluene; at 50 ℃; for 4h; Further byproducts given;

DOI:10.1515/znb-1981-0924

Reference yield: 50.3%

4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3) + prenyl bromide (870-63-3) → 3,3-bis(γ,γ-dimethylallyl)-2.4-dioxo-1,2,3,4-tetrahydroquinoline (21873-59-6) + 4-hydroxy-3-(3-methylbut-2-enyl) quinolin-2(1H)one (6431-84-1) + 4-(3',3'-Dimethylallyloxy)-3-(3'',3''-dimethylallyl)-2-chinolon (18118-29-1) + 4-(3',3'-Dimethylallyloxy)-2-chinolon (54357-78-7) + 3-(1',1'-Dimethylallyl)-4-hydroxy-2-chinolon + 4-(3',3'-Dimethylallyloxy)-3-(1'',1''-dimethylallyl)-2-chinolon

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In toluene; at 50 ℃; for 4h; Product distribution;

DOI:10.1515/znb-1981-0924

upstream raw materials:

4-Hydroxy-2-quinolone

prenyl bromide