Benzimidazole, 1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1.6 hydrate

Base Information

• Chemical Name: Benzimidazole, 1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1.6 hydrate
• CAS No.: 85573-17-7
• Molecular Formula: C20H16N2O2
• Molecular Weight: 316.359
• Hs Code.: 2933990090
• Mol file: 85573-17-7.mol

Synonyms:1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1H-1,3-benzimidazole;4-[1-(4-hydroxybenzyl)-1H-benzo[d]imidazol-2-yl]phenol;1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1H-benzimidazole;4-{[2-(4-hydroxyphenyl)-1H-benzimidazol-1-yl]methyl}phenol;1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1H-benzo[d]imidazole;

Chemical Property of Benzimidazole, 1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1.6 hydrate

Chemical Property:

• Vapor Pressure: 8.35E-11mmHg at 25°C
• Boiling Point: 504.6°Cat760mmHg
• Flash Point: 259°C
• PSA: 58.28000
• Density: 1.347g/cm³
• LogP: 4.16280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzimidazole, 1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1.6 hydrate

There total 4 articles about Benzimidazole, 1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1.6 hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + 1,2-diamino-benzene (95-54-5) → 1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1H-benzo[d]imidazole (85573-17-7)

Guidance literature:

at 30 ℃; for 0.366667h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1039/c5gc00536a

Reference yield: 91.0%

4,4′-[1,2-phenylenebis(nitrilomethylidene)]bisphenol (74661-50-0) → 1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1H-benzo[d]imidazole (85573-17-7)

Guidance literature:

With toluene-4-sulfonic acid; In neat (no solvent); Milling; Green chemistry;

DOI:10.1134/S1070428020090201

Reference yield: 86.1%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + 1,2-diamino-benzene (95-54-5) → 4-(1H-benzimidazol-2-yl)phenol (6504-13-8) + 1-(4-hydroxybenzyl)-2-(4-hydroxyphenyl)-1H-benzo[d]imidazole (85573-17-7)

Guidance literature:

With silica gel supported trichloroacetic acid; In ethanol; water; at 50 ℃; for 0.15h; regioselective reaction; Sonication; Green chemistry;

DOI:10.1007/s12039-014-0662-4

upstream raw materials:

4-hydroxy-benzaldehyde

1,2-diamino-benzene

4,4′-[1,2-phenylenebis(nitrilomethylidene)]bisphenol

Downstream raw materials:

[RuCl₃(1-p-hydroxybenzyl-2-p-hydroxyphenylbenzimidazole)2(H₂O)2]