Naphthalene, 1,2,3,4-tetrahydro-6-(2-(4-(methoxymethyl)phenyl)-1-methylethenyl)-1,1,4,4-tetramethyl-, (E)-

Base Information

• Chemical Name: Naphthalene, 1,2,3,4-tetrahydro-6-(2-(4-(methoxymethyl)phenyl)-1-methylethenyl)-1,1,4,4-tetramethyl-, (E)-
• CAS No.: 71441-32-2
• Molecular Formula: C₂₅H₃₂O
• Molecular Weight: 348.528
• Mol file: 71441-32-2.mol

Synonyms:1,2,3,4-Tetrahydro-6-(2-(4-(methoxymethyl)phenyl)-1-methylethenyl)-1-1,1,4,4-tetramethyl-naphthalene, (e)-;71441-32-2;Naphthalene, 1,2,3,4-tetrahydro-6-(2-(4-(methoxymethyl)phenyl)-1-methylethenyl)-1,1,4,4-tetramethyl-, (E)-;SCHEMBL7085841

Chemical Property of Naphthalene, 1,2,3,4-tetrahydro-6-(2-(4-(methoxymethyl)phenyl)-1-methylethenyl)-1,1,4,4-tetramethyl-, (E)-

Chemical Property:

• Vapor Pressure: 1.53E-07mmHg at 25°C
• Boiling Point: 440.4°Cat760mmHg
• Flash Point: 243.6°C
• Density: 0.98g/cm³
• XLogP3: 7.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 348.245315640
• Heavy Atom Count: 26
• Complexity: 492

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=CC1=CC=C(C=C1)COC)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
• Isomeric SMILES: C/C(=C\C1=CC=C(C=C1)COC)/C2=CC3=C(C=C2)C(CCC3(C)C)(C)C

Technology Process of Naphthalene, 1,2,3,4-tetrahydro-6-(2-(4-(methoxymethyl)phenyl)-1-methylethenyl)-1,1,4,4-tetramethyl-, (E)-

There total 7 articles about Naphthalene, 1,2,3,4-tetrahydro-6-(2-(4-(methoxymethyl)phenyl)-1-methylethenyl)-1,1,4,4-tetramethyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)ethanone (17610-21-8) → p-<(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-propenyl>-benzyl methyl ether (71441-32-2)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium borohydride / methanol / 1.5 h / 0 °C

2: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C

3: diethyl ether; xylene / 48 h / 100 °C

4: 69.3 percent / butylene oxide / 12 h / 65 °C

5: 89 percent / lithium aluminum hydride / tetrahydrofuran; diethyl ether / 0 - 5 °C

6: 1.) sodium hydride / 1.) DMF, rt, 1h; 2.) rt, 2 h

With tetrahydrofuran; sodium tetrahydroborate; lithium aluminium tetrahydride; phosphorus tribromide; sodium hydride; pyridine; In tetrahydrofuran; methanol; diethyl ether; hexane; xylene;

Reference yield:

5,6,7,8-tetrahydro-α,5,5,8,8-pentamethyl-2-naphthalene methanol (69251-25-8) → p-<(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-propenyl>-benzyl methyl ether (71441-32-2)

Guidance literature:

Multi-step reaction with 5 steps

1: phosphorus tribromide / pyridine / diethyl ether; hexane / 2.5 h / 0 - 5 °C

2: diethyl ether; xylene / 48 h / 100 °C

3: 69.3 percent / butylene oxide / 12 h / 65 °C

4: 89 percent / lithium aluminum hydride / tetrahydrofuran; diethyl ether / 0 - 5 °C

5: 1.) sodium hydride / 1.) DMF, rt, 1h; 2.) rt, 2 h

With tetrahydrofuran; lithium aluminium tetrahydride; phosphorus tribromide; sodium hydride; pyridine; In tetrahydrofuran; diethyl ether; hexane; xylene;

Reference yield:

AGN 190316 (71441-09-3) → p-<(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-propenyl>-benzyl methyl ether (71441-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / lithium aluminum hydride / tetrahydrofuran; diethyl ether / 0 - 5 °C

2: 1.) sodium hydride / 1.) DMF, rt, 1h; 2.) rt, 2 h

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether;

upstream raw materials:

AGN 190316

1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)ethanone

[1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-ethyl]-triphenylphosphonium bromide

2-(bromoethyl)-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene