o-Chloro-N-(p-methoxyphenyl)benzamidine

Base Information

• Chemical Name: o-Chloro-N-(p-methoxyphenyl)benzamidine
• CAS No.: 23564-74-1
• Molecular Formula: C14H13 Cl N2 O
• Molecular Weight: 260.723
• Hs Code.: 2925290090
• Mol file: 23564-74-1.mol

Synonyms:Benzamidine,o-chloro-N-(p-methoxyphenyl)- (8CI); N-(p-Methoxyphenyl)-2-chlorobenzamidine

Chemical Property of o-Chloro-N-(p-methoxyphenyl)benzamidine

Chemical Property:

• Boiling Point: 424°Cat760mmHg
• Flash Point: 210.2°C
• PSA: 0.00000
• Density: 1.19g/cm³
• LogP: 2.19140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-Chloro-N-(p-methoxyphenyl)benzamidine

There total 2 articles about o-Chloro-N-(p-methoxyphenyl)benzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chlorobenzonitrile (873-32-5) + 4-methoxy-aniline (104-94-9) → 2-chloro-N-(4-methoxyphenyl)benzimidamide (23564-74-1)

Guidance literature:

With ethylmagnesium bromide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2007.03.011

Reference yield:

→ 2-chloro-N-(4-methoxyphenyl)benzimidamide (23564-74-1)

Guidance literature:

o-Chlorbenzonitril, p-Methoxy-anilin;

Reference yield: 92.0%

2-chloro-N-(4-methoxyphenyl)benzimidamide (23564-74-1) → N-(4-methoxyphenyl)benzo[d]isothiazol-3-amine

Guidance literature:

With potassium phosphate tribasic trihydrate; sulfur; In dimethyl sulfoxide; toluene; at 135 ℃; for 36h;

DOI:10.1039/c7gc03599c

upstream raw materials:

2-Chlorobenzonitrile

4-methoxy-aniline

Refernces

• 1、 Xie, Hao,Li, Guozheng,Zhang, Feng,Xiao, Fuhong,Deng, Guo-Jun. "Efficient synthesis of 1,2-benzisothiazoles from: O -haloarylamidines and elemental sulfur via N-S/C-S bond formation under transition-metal-free conditions". supporting information. p. 827 - 831. Retrieved 2018/03/02.