2-Hydroxytetracosanoic acid

Base Information

• Chemical Name: 2-Hydroxytetracosanoic acid
• CAS No.: 544-57-0
• Molecular Formula: C24H48O3
• Molecular Weight: 384.643
• Hs Code.: 2918199090
• UNII: 66QN3B074E
• DSSTox Substance ID: DTXSID40969526
• Nikkaji Number: J297.220D
• Wikidata: Q11751627
• Metabolomics Workbench ID: 1338
• Mol file: 544-57-0.mol

Synonyms:cerebronic acid

Chemical Property of 2-Hydroxytetracosanoic acid

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 1.75E-12mmHg at 25°C
• Melting Point: 101oC to 104oC
• Refractive Index: 1.469
• Boiling Point: 508.8 °C at 760 mmHg
• Flash Point: 275.6 °C
• PSA: 57.53000
• Density: 0.921 g/cm³
• LogP: 7.64390
• XLogP3: 10.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 22
• Exact Mass: 384.36034539
• Heavy Atom Count: 27
• Complexity: 304

Purity/Quality:

98%Min ^*data from raw suppliers

2-hydroxy Lignoceric Acid ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCCCCCCCCC(C(=O)O)O

Technology Process of 2-Hydroxytetracosanoic acid

There total 9 articles about 2-Hydroxytetracosanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(+/-)-2-bromotetracosanoic acid (102809-35-8) → 2-hydroxytetracosanoic acid (544-57-0)

Guidance literature:

With sodium hydroxide; at 85 ℃; for 30h;

DOI:10.1002/ejoc.200500357

Reference yield:

n-tetracosanoic acid (557-59-5) → 2-hydroxytetracosanoic acid (544-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / red phosphorus; bromine / 6 h / 95 °C

2: 97 percent / aq. NaOH / 30 h / 85 °C

With phosphorus; sodium hydroxide; bromine;

DOI:10.1002/ejoc.200500357

Reference yield:

2-hydroxy-tetracos-15-enoic acid (95746-76-2) → 2-hydroxytetracosanoic acid (544-57-0)

Guidance literature:

With ethanol; hydrogen; palladium dichloride; at 60 - 70 ℃; under 380 Torr; dextrorotatory α-oxy-lignoceric acid; und einer Spur Gummi arabicum Ueberdruck;

upstream raw materials:

(+/-)-2-bromotetracosanoic acid

2-hydroxy-tetracos-15-enoic acid

ethanol

n-tetracosanoic acid

Downstream raw materials:

n-tetracosanoic acid

tricosanoic acid

tricosanoic acid methyl ester

2-acetoxy-tetracosanoic acid pentafluorophenyl ester

Refernces

• 1、 -. "Compositions and methods for enhancing the topical effects of sunscreen agents". . . Retrieved 2008/06/13.