(2,5-Dichlorophenyl)hydrazine

Base Information

• Chemical Name: (2,5-Dichlorophenyl)hydrazine
• CAS No.: 305-15-7
• Molecular Formula: C6H6Cl2N2
• Molecular Weight: 177.033
• Hs Code.: 29280000
• European Community (EC) Number: 206-163-6
• NSC Number: 6102
• DSSTox Substance ID: DTXSID1059789
• Nikkaji Number: J49.479H
• Wikidata: Q81988959
• Mol file: 305-15-7.mol

Synonyms:2,5-Dichlorophenylhydrazine;305-15-7;(2,5-Dichlorophenyl)hydrazine;HYDRAZINE, (2,5-DICHLOROPHENYL)-;NSC 6102;EINECS 206-163-6;BRN 0743382;(2,5-Dichloro-phenyl)-hydrazine;1-(2,5-Dichlorophenyl)hydrazine;0-15-00-00431 (Beilstein Handbook Reference);2,5-dichlorophenyl hydrazine;NSC6102;WLN: ZMR BG EG;2,5-dichloro-phenylhydrazine;Hydrazine,5-dichlorophenyl)-;2,5-Dichloro Phenylhydrazine;SCHEMBL1132624;DTXSID1059789;LZKWWERBNXLGLI-UHFFFAOYSA-;2,5-Dichlorophenylhydrazine, 98%;NSC-6102;1-(2,5-Dichlorophenyl)hydrazine #;MFCD00007576;STL356333;AKOS002680111;AC-10698;LS-76724;BB 0249748;CS-0328005;FT-0610326;W-106938

Chemical Property of (2,5-Dichlorophenyl)hydrazine

Chemical Property:

• Appearance/Colour: light brown powder
• Vapor Pressure: 0.00848mmHg at 25°C
• Melting Point: 102-103 °C(lit.)
• Refractive Index: 1.665
• Boiling Point: 266.8 °C at 760 mmHg
• PKA: 4.32±0.10(Predicted)
• Flash Point: 115.1 °C
• PSA: 38.05000
• Density: 1.476 g/cm³
• LogP: 3.05230
• Storage Temp.: Keep Cold
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 175.9908036
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dichlorophenylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T
• Hazard Codes: T,Xi
• Statements: 25-36
• Safety Statements: 26-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)NN)Cl
• Uses: 2,5-Dichlorophenylhydrazine was used in the preparation of D-erythrose 2,5-dichlorophenylhydrazon.

Technology Process of (2,5-Dichlorophenyl)hydrazine

There total 5 articles about (2,5-Dichlorophenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.8%

2,5 dichloroaniline (95-82-9) → (2,5-dichlorophenyl)hydrazine (305-15-7)

Guidance literature:

2,5 dichloroaniline; With hydrogenchloride; sodium nitrite; at 0 ℃; for 0.5h;

With tin(ll) chloride; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2018.05.028

Reference yield:

2,5,2',5'-tetrachlorodiazoaminobenzene (893-39-0) → (2,5-dichlorophenyl)hydrazine (305-15-7)

Guidance literature:

With hydrogenchloride; tin(ll) chloride;

DOI:10.1016/S0889-5406(00)70225-3

Reference yield:

2,5-dichlorophenyl-diazonium chloride (120-28-5) → (2,5-dichlorophenyl)hydrazine (305-15-7)

Guidance literature:

With tin(ll) chloride;

upstream raw materials:

2,5 dichloroaniline

2,5,2',5'-tetrachlorodiazoaminobenzene

2,5-dichlorophenyl-diazonium chloride

hydrogenchloride

Downstream raw materials:

maleic acid mono-[N'-(2,5-dichloro-phenyl)-hydrazide]

(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl)-acetic acid-[N'-(2,5-dichloro-phenyl)-hydrazide]

2-(2,5-dichloro-phenyl)-5-methyl-1,2-dihydro-pyrazol-3-one

(2S)-2t-hydroxymethyl-[1,3]dioxolane-2r,4c-dicarbaldehyde-bis-(2,5-dichloro-phenylhydrazone)

Refernces

• 1、 Liu, Jing-Bo,Li, Feng-Yun,Dong, Jing-Yue,Li, Yu-Xin,Zhang, Xiu-Lan,Wang, Yuan-Hong,Xiong, Li-Xia,Li, Zheng-Ming. "Anthranilic diamides derivatives as potential ryanodine receptor modulators: Synthesis, biological evaluation and structure activity relationship". . p. 3541 - 3550. Retrieved 2018/06/19.
• 2、 Nagarajan, K.,Talwalker, P.K.,Kulkarni, C.L.,Venkateswarlu, A.,Prabhu, S.S.,Nayak, G.V.. "Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides". . p. 1243 - 1257. Retrieved 2007/10/02.