6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-chloro-, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide

Base Information

• Chemical Name: 6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-chloro-, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide
• CAS No.: 109322-03-4
• Molecular Formula: C₂₄H₁₈ClN₅O₃
• Molecular Weight: 459.892
• Mol file: 109322-03-4.mol

Synonyms:6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-chloro-, [(4-hydroxy-3-methoxyphenyl)methylene]hydrazide (9CI)

Chemical Property of 6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-chloro-, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide

Chemical Property:

• Boiling Point: 642.9°Cat760mmHg
• Flash Point: 342.6°C
• Density: 1.45g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-chloro-, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide

There total 3 articles about 6H-Indolo[2,3-b]quinoxaline-6-aceticacid, 2-chloro-, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

vanillin (121-33-5,8014-42-4) + 2-chloroindophenazin-6-acetic acid hydrazide (109321-97-3) → (2-Chloro-indolo[2,3-b]quinoxalin-6-yl)-acetic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide (109322-03-4)

Guidance literature:

With acetic acid; In ethanol; for 4h; Heating;

Reference yield:

2-chloroindophenazine (96340-01-1) → (2-Chloro-indolo[2,3-b]quinoxalin-6-yl)-acetic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide (109322-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / K₂CO₃ / acetone / 20 h / Heating

2: 90 percent / hydrazine hydrate / ethanol / 6 h / Heating

3: 70 percent / glac.HOAc / ethanol / 4 h / Heating

With potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; acetone;

Reference yield:

6-carbethoxymethyl-2-chloroindophenazine (109321-95-1) → (2-Chloro-indolo[2,3-b]quinoxalin-6-yl)-acetic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide (109322-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / hydrazine hydrate / ethanol / 6 h / Heating

2: 70 percent / glac.HOAc / ethanol / 4 h / Heating

With hydrazine hydrate; acetic acid; In ethanol;

upstream raw materials:

vanillin

2-chloroindophenazin-6-acetic acid hydrazide

2-chloroindophenazine

6-carbethoxymethyl-2-chloroindophenazine