HYPOPHYLLANTHIN

Base Information

Chemical Name:HYPOPHYLLANTHIN
CAS No.:33676-00-5
Molecular Formula:C₂₄H₃₀O₇
Molecular Weight:430.498
Hs Code.:
Mol file:33676-00-5.mol

Synonyms:Hypophyllanthin(7CI); Naphthalene, 1a-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6-methoxy-2b,3a-bis(methoxymethyl)-7,8-(methylenedioxy)- (8CI);Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7R,8R,9S)-rel- (9CI); Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7a,8b,9a)-; NSC 619044

Suppliers and Price of HYPOPHYLLANTHIN

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Hypophyllanthin phyproof? Reference Substance
10 mg
$ 584.00

ChemScene
Hypophyllanthin 98.40%
5mg
$ 315.00

ChemScene
Hypophyllanthin 98.40%
1mg
$ 125.00

Cayman Chemical
Hypophyllanthin ≥98%
10mg
$ 399.00

Cayman Chemical
Hypophyllanthin ≥98%
25mg
$ 860.00

Cayman Chemical
Hypophyllanthin ≥98%
1mg
$ 54.00

Cayman Chemical
Hypophyllanthin ≥98%
5mg
$ 240.00

Biosynth Carbosynth
Hypophyllanthin
100 mg
$ 1300.00

Biosynth Carbosynth
Hypophyllanthin
10 mg
$ 180.00

Biosynth Carbosynth
Hypophyllanthin
5 mg
$ 125.00

Total 26 raw suppliers

Chemical Property of HYPOPHYLLANTHIN

Chemical Property:

Vapor Pressure:4.67E-10mmHg at 25°C
Melting Point:129-130℃
Boiling Point:511.1°Cat760mmHg
Flash Point:200.8°C
PSA：64.61000
Density:1.158g/cm³
LogP:3.65430
Solubility.:≤0.2mg/ml in ethanol;10mg/ml in DMSO;30mg/ml in dimethyl formamide

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hypophyllanthin phyproof? Reference Substance ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Description Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity. In Caco-2 cells 100 μM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.
Uses Hypophyllanthin can be used to study the modulation of NSAID-induced, ER stress-mediated apoptosis in Caco-2 cells by different polyphenolic antioxidants.

Technology Process of HYPOPHYLLANTHIN

There total 2 articles about HYPOPHYLLANTHIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82423-78-7
r-1-(3,4-dimethoxyphenyl)-t-2,c-3-bishydroxymethyl-6-methoxy-7,8-methylenedioxy-1,2,3,4-tetrahydronaphthalene

: 74-88-4
methyl iodide

: 33676-00-5,78215-54-0
(+/-)-hypophyllanthin

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; for 2.5h; Ambient temperature;

Reference yield:

: 78246-77-2
(6aR,9aR,10S)-5-Bromo-10-(3,4-dimethoxy-phenyl)-4-methoxy-6a,7,9a,10-tetrahydro-6H-furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-9-one

: 74-88-4
methyl iodide

: 33676-00-5,78215-54-0
(+/-)-hypophyllanthin

Guidance literature:: With lithium aluminium tetrahydride; Multistep reaction;
DOI:10.1016/0040-4039(81)80108-6

Reference yield:

: 33676-00-5,78215-54-0
Hypophyllanthin

: 79606-77-2
9-(3,4-Dimethoxy-phenyl)-4-methoxy-8-methoxymethyl-naphtho[1,2-d][1,3]dioxole-7-carbaldehyde

: 79606-76-1
(8R,9S)-9-(3,4-Dimethoxy-phenyl)-4-methoxy-8-methoxymethyl-8,9-dihydro-naphtho[1,2-d][1,3]dioxole-7-carbaldehyde

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 24h; Ambient temperature;
DOI:10.1016/S0040-4039(01)81817-7