ethyl 5-cyano-2-ethyl-1,6-dihydro-6-oxo-3-pyridinecarboxylate

Base Information

• Chemical Name: ethyl 5-cyano-2-ethyl-1,6-dihydro-6-oxo-3-pyridinecarboxylate
• CAS No.: 121017-74-1
• Molecular Formula: C₁₁H₁₂N₂O₃
• Molecular Weight: 220.228
• Mol file: 121017-74-1.mol

Synonyms:Ethyl5-cyano-2-ethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Chemical Property of ethyl 5-cyano-2-ethyl-1,6-dihydro-6-oxo-3-pyridinecarboxylate

Chemical Property:

• Vapor Pressure: 4.78E-06mmHg at 25°C
• Boiling Point: 382.3°Cat760mmHg
• Flash Point: 185°C
• PSA: 82.95000
• Density: 1.22g/cm³
• LogP: 0.98568

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 5-cyano-2-ethyl-1,6-dihydro-6-oxo-3-pyridinecarboxylate

There total 3 articles about ethyl 5-cyano-2-ethyl-1,6-dihydro-6-oxo-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-[1-dimethylaminomethylidene]-3-oxo-pentanoic acid ethyl ester (89193-23-7) → ethyl 5-cyano-2-ethyl-6-oxo-1,6-dihydropyridine-3-carboxylate (121017-74-1)

Guidance literature:

cyanoacetic acid amide; With sodium hydride; In tetrahydrofuran; at 20 ℃;

2-[1-dimethylaminomethylidene]-3-oxo-pentanoic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield: 81.0%

2-[1-dimethylaminomethylidene]-3-oxo-pentanoic acid ethyl ester (89193-23-7) + cyanoacetic acid amide (107-91-5) → ethyl 5-cyano-2-ethyl-6-oxo-1,6-dihydropyridine-3-carboxylate (121017-74-1)

Guidance literature:

cyanoacetic acid amide; With sodium hydride; In tetrahydrofuran; at 20 ℃;

2-[1-dimethylaminomethylidene]-3-oxo-pentanoic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield: 40.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + cyanoacetic acid amide (107-91-5) + ethyl propanoylacetate (4949-44-4) → ethyl 5-cyano-2-ethyl-6-oxo-1,6-dihydropyridine-3-carboxylate (121017-74-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1055/s-1995-3954

upstream raw materials:

2-[1-dimethylaminomethylidene]-3-oxo-pentanoic acid ethyl ester

cyanoacetic acid amide

N,N-dimethyl-formamide dimethyl acetal

ethyl propanoylacetate

Downstream raw materials:

3-cyano-6-ethyl-2(1H)-pyridinone

Refernces

• 1、 -. "NEW PYRIDINE ANALOGUES". Page/Page column 114-115. . Retrieved 2008/06/13.
• 2、 Abu-Shanab,Redhouse,Thompson,Wakefield. "Synthesis of 2,3,5,6-tetrasubstituted pyridines from enamines derived from N,N-dimethylformamide dimethyl acetal". . p. 557 - 560. Retrieved 2007/10/02.