1-Hydroxycyclopentanecarboxylic acid

Base Information

• Chemical Name: 1-Hydroxycyclopentanecarboxylic acid
• CAS No.: 16841-19-3
• Molecular Formula: C6H10 O3
• Molecular Weight: 130.144
• Hs Code.: 2918199090
• European Community (EC) Number: 675-134-1
• NSC Number: 64918,64727
• UNII: 468D8R6F8N
• DSSTox Substance ID: DTXSID70901494
• Nikkaji Number: J48.253F
• Mol file: 16841-19-3.mol

Synonyms:1-Hydroxycyclopentanecarboxylic acid;16841-19-3;1-Hydroxy-cyclopentanecarboxylic acid;1-hydroxycyclopentane-1-carboxylic acid;Cyclopentanecarboxylic acid, 1-hydroxy-;1-Hydroxy-1-cyclopentanecarboxylic acid;468D8R6F8N;MFCD00045414;NSC-64727;NSC-64918;WLN: L5TJ AVQ AQ;NSC 64727;NSC 64918;NoName_619;NCIOpen2_000164;NCIOpen2_000218;SCHEMBL756943;UNII-468D8R6F8N;NIOSH/GY2790000;DTXSID70901494;1-Hydroxycyclopentanecarboxylicacid;JJABOWZNFOCHMN-UHFFFAOYSA-N;AMY40976;NSC64727;NSC64918;1-hydroxycyclopentane-carboxylic acid;RB3239;STL301922;AKOS001302540;CB 1693;CS-W006221;BS-13024;SY031777;A3724;BB 0256922;FT-0682353;GY27900000;1-HYDROXYCYCLOPENTAN-1-CARBOXYLIC ACID;EN300-25960;1-Hydroxycyclopentanecarboxylic acid, AldrichCPR;J-010454;Z220335554

Chemical Property of 1-Hydroxycyclopentanecarboxylic acid

Chemical Property:

• Melting Point: 103-104℃
• Boiling Point: 287.5°Cat760mmHg
• PKA: 4.05±0.20(Predicted)
• Flash Point: 141.9°C
• PSA: 57.53000
• Density: 1.35g/cm³
• LogP: 0.37610
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 130.062994177
• Heavy Atom Count: 9
• Complexity: 124

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Hydroxycyclopentanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)(C(=O)O)O
• Uses: 1-Hydroxycyclopentanecarboxylic Acid is a reagent used in the preparation of pyridone-conjugated monobactam antibiotics showing gram-negative activity.

Technology Process of 1-Hydroxycyclopentanecarboxylic acid

There total 32 articles about 1-Hydroxycyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-[(trimethylsilyl)oxy]cyclopentanecarbonitrile (25438-35-1) → 1-hydroxy-cyclopentanecarboxylic acid (16841-19-3)

Guidance literature:

With hydrogenchloride; In acetic acid; at 80 ℃; for 4h;

Reference yield: 80.0%

1-hydroxycyclopentanecarbonitrile (5117-85-1) → 1-hydroxy-cyclopentanecarboxylic acid (16841-19-3)

Guidance literature:

With hydrogenchloride; acetic acid; for 10h;

Reference yield: 74.0%

trimethylsilyl cyanide (7677-24-9) + cyclopentanone (120-92-3) → 1-hydroxy-cyclopentanecarboxylic acid (16841-19-3)

Guidance literature:

trimethylsilyl cyanide; cyclopentanone; With zinc(II) chloride; In tetrahydrofuran; dichloromethane; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; at 20 - 100 ℃; for 6h;

upstream raw materials:

Adipic acid

1,2-Cyclohexanediol

2,6-dibromocyclohexanone

1-acetylcyclopentanol

Downstream raw materials:

C₃₈H₆₃N₅O₇

1-methoxycyclopentanecarboxylic acid

C₄₈H₅₂N₈O₁₁S

(phenylmethyl) 1-hydroxy-1-cyclopentanecarboxylate

Refernces

• 1、 Solmi, Stefania,Rozhko, Elena,Malmusi, Andrea,Tabanelli, Tommaso,Albonetti, Stefania,Basile, Francesco,Agnoli, Stefano,Cavani, Fabrizio. "The oxidative cleavage of trans-1,2-cyclohexanediol with O2: Catalysis by supported Au nanoparticles". . p. 89 - 98. Retrieved 2018/04/06.
• 2、 -. "Anesthetic compounds and related methods of use". Page/Page column 64. . Retrieved 2015/11/09.