5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-2-oxazolidinone

Base Information

• Chemical Name: 5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-2-oxazolidinone
• CAS No.: 29218-19-7
• Molecular Formula: C₁₁H₁₀F₃NO₃
• Molecular Weight: 261.201
• Hs Code.: 2934999090
• Mol file: 29218-19-7.mol

Synonyms:2-Oxazolidinone,5-(hydroxymethyl)-3-(a,a,a-trifluoro-m-tolyl)- (8CI)

Chemical Property of 5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-2-oxazolidinone

Chemical Property:

• Vapor Pressure: 3.1E-05mmHg at 25°C
• Boiling Point: 341.5°Cat760mmHg
• Flash Point: 160.3°C
• PSA: 49.77000
• Density: 1.422g/cm³
• LogP: 2.08790

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-2-oxazolidinone

There total 2 articles about 5-(Hydroxymethyl)-3-[3-(trifluoromethyl)phenyl]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-hydroxymethyl-3-(3-trifluoromethyl-phenyl)-oxazolidin-2-one (29218-19-7)

Guidance literature:

Darst.;

Reference yield:

3-(3-trifluoromethyl-anilino)-propane-1,2-diol (42902-54-5) + Diethyl carbonate (105-58-8,76619-83-5) → 5-hydroxymethyl-3-(3-trifluoromethyl-phenyl)-oxazolidin-2-one (29218-19-7)

Guidance literature:

Multistep reaction; (i), (ii) NaOMe, MeOH;

Reference yield:

phosgene (75-44-5) + 5-hydroxymethyl-3-(3-trifluoromethyl-phenyl)-oxazolidin-2-one (29218-19-7) → 5-carbamoyloxymethyl-3-(3-trifluoromethyl-phenyl)-oxazolidin-2-one (29218-20-0)

Guidance literature:

Multistep reaction; (i) PhNEt₂, toluene, (ii) NH₃, benzene;

upstream raw materials:

3-(3-trifluoromethyl-anilino)-propane-1,2-diol

Diethyl carbonate

Downstream raw materials:

5-carbamoyloxymethyl-3-(3-trifluoromethyl-phenyl)-oxazolidin-2-one

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