(E)-2-cyano-N-(2-methoxyphenyl)-3-(1-prop-2-enylindol-3-yl)prop-2-enamide

Base Information

Chemical Name:(E)-2-cyano-N-(2-methoxyphenyl)-3-(1-prop-2-enylindol-3-yl)prop-2-enamide
CAS No.:5971-86-8
Molecular Formula:C22H19N3O2
Molecular Weight:357.4052
Hs Code.:
DSSTox Substance ID:DTXSID10362080
Wikidata:Q82144816

Synonyms:5971-86-8;(E)-2-cyano-N-(2-methoxyphenyl)-3-(1-prop-2-enylindol-3-yl)prop-2-enamide;ZINC01201557;DTXSID10362080

Suppliers and Price of (E)-2-cyano-N-(2-methoxyphenyl)-3-(1-prop-2-enylindol-3-yl)prop-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (E)-2-cyano-N-(2-methoxyphenyl)-3-(1-prop-2-enylindol-3-yl)prop-2-enamide

Chemical Property:

Vapor Pressure:4.6E-15mmHg at 25°C
Boiling Point:615.1°Cat760mmHg
Flash Point:325.8°C
Density:1.13g/cm³
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:357.147726857
Heavy Atom Count:27
Complexity:620

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1NC(=O)C(=CC2=CN(C3=CC=CC=C32)CC=C)C#N
Isomeric SMILES:COC1=CC=CC=C1NC(=O)/C(=C/C2=CN(C3=CC=CC=C32)CC=C)/C#N

Technology Process of (E)-2-cyano-N-(2-methoxyphenyl)-3-(1-prop-2-enylindol-3-yl)prop-2-enamide

There total 6 articles about (E)-2-cyano-N-(2-methoxyphenyl)-3-(1-prop-2-enylindol-3-yl)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 111971-08-5
3-benzyl-6-(methoxycarbonyl)-2-ureido-4-oxo-3,4-dihydropyrimidine

: 5971-86-8
3-benzylorotic acid

Guidance literature:: With sodium hydroxide; for 3h; Heating;
DOI:10.1021/jo00266a013

Reference yield:

: 111971-01-8
C₁₄H₁₅N₃O₅

: 5971-86-8
3-benzylorotic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / propan-2-ol / 1.5 h / Heating

2: 61 percent / bromine / acetic acid / 0.17 h / Heating

3: 51 percent / 2 M NaOH / 3 h / Heating

With sodium hydroxide; bromine; In acetic acid; isopropyl alcohol;
DOI:10.1021/jo00266a013

Reference yield:

: 111971-05-2
1-Benzyl-2-[(Z)-cyanoimino]-6-oxo-hexahydro-pyrimidine-4-carboxylic acid methyl ester

: 5971-86-8
3-benzylorotic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / bromine / acetic acid / 0.17 h / Heating

2: 51 percent / 2 M NaOH / 3 h / Heating

With sodium hydroxide; bromine; In acetic acid;
DOI:10.1021/jo00266a013