1-benzyl-N-(4-bromo-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

Base Information

• Chemical Name: 1-benzyl-N-(4-bromo-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide
• CAS No.: 1254836-87-7
• Molecular Formula: C₂₀H₁₅BrF₃N₃O₄
• Molecular Weight: 498.256

Synonyms:1-benzyl-N-(4-bromo-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

Chemical Property of 1-benzyl-N-(4-bromo-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

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Technology Process of 1-benzyl-N-(4-bromo-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

There total 1 articles about 1-benzyl-N-(4-bromo-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{4-bromo-2-[(trifluoromethyl)oxy]phenyl}methanamine (947583-96-2) + 3-benzylorotic acid (5971-86-8) → 1-benzyl-N-(4-bromo-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide (1254836-87-7)

Guidance literature:

With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

zinc(II) cyanide (557-21-1) + 1-benzyl-N-(4-bromo-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide (1254836-87-7) → 1-benzyl-N-(4-cyano-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide (1254838-06-6)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere; microwave tube;

Reference yield:

sodium cyclopropylsulfinate (910209-21-1) + 1-benzyl-N-(4-bromo-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide (1254836-87-7) → 1-benzyl-N-(4-(cyclopropylsulfonyl)-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide (1254837-93-8)

Guidance literature:

With copper(l) iodide; In dimethyl sulfoxide; ethylenediamine; at 150 ℃; for 1h; Inert atmosphere; microwave tube;

upstream raw materials:

1-{4-bromo-2-[(trifluoromethyl)oxy]phenyl}methanamine

3-benzylorotic acid

Downstream raw materials:

1-benzyl-N-(4-cyano-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

1-benzyl-N-(4-(cyclopropylsulfonyl)-2-(trifluoromethoxy)benzyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

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