Moracin F

Base Information

• Chemical Name: Moracin F
• CAS No.: 73338-85-9
• Molecular Formula: C₁₆H₁₄O₅
• Molecular Weight: 286.284
• DSSTox Substance ID: DTXSID301237691
• Metabolomics Workbench ID: 45978
• ChEMBL ID: CHEMBL3397393
• Mol file: 73338-85-9.mol

Synonyms:Moracin F;5-(5,6-dimethoxy-1-benzofuran-2-yl)benzene-1,3-diol;CHEMBL3397393;CHEBI:174727;DTXSID301237691;2-(3,5-Dihydroxyphenyl)-5,6-dimethoxybenzofuran;5-(5,6-Dimethoxy-2-benzofuranyl)-1,3-benzenediol;5-(5,6-dimethoxy-1-benzouran-2-yl)benzene-1,3-diol;73338-85-9

Chemical Property of Moracin F

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 286.08412354
• Heavy Atom Count: 21
• Complexity: 340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C=C(O2)C3=CC(=CC(=C3)O)O)OC

Technology Process of Moracin F

There total 21 articles about Moracin F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

((5-(5,6-dimethoxybenzofuran-2-yl)-1,3-phenylene)-bis(oxy))-bis(tert-butyldimethylsilane) → 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran (73338-85-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1002/bkcs.10847

Reference yield: 86.0%

2-(3,5-bis(allyloxy)phenyl)-5,6-dimethoxybenzofuran → 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran (73338-85-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1002/bkcs.10847

Reference yield: 75.0%

2-(3,5-bis(ethoxymethoxy)phenyl)-5,6-dimethoxybenzofuran → 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran (73338-85-9)

Guidance literature:

With Dowex₅₀X₂-100; In methanol; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/bkcs.10847

upstream raw materials:

3,5-bis(allyloxy)benzoic acid

3,5-bis(allyloxy)benzoic acid chloride

2-hydroxy-4,5-dimethoxybenzaldehyde

3,5-dihydroxyacetophenone