3,5-BIS(ALLYLOXY)BENZENECARBOXYLIC ACID

Base Information

• Chemical Name: 3,5-BIS(ALLYLOXY)BENZENECARBOXYLIC ACID
• CAS No.: 185254-52-8
• Molecular Formula: C13H14O4
• Molecular Weight: 234.252
• Mol file: 185254-52-8.mol

Synonyms:3,5-Bis-allyloxy-benzoic acid;3,5-diallyloxybenzoic acid;

Chemical Property of 3,5-BIS(ALLYLOXY)BENZENECARBOXYLIC ACID

Chemical Property:

• Melting Point: 64 - 66 °C
• Boiling Point: 401.6±35.0 °C(Predicted)
• PKA: 4.02±0.10(Predicted)
• PSA: 55.76000
• Density: 1.136±0.06 g/cm3(Predicted)
• LogP: 2.51440

Purity/Quality:

3,5-Bis(allyloxy)benzenecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-BIS(ALLYLOXY)BENZENECARBOXYLIC ACID

There total 6 articles about 3,5-BIS(ALLYLOXY)BENZENECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,5-bis(2-propen-1-yloxy)benzoic acid methyl ester (135710-38-2) → 3,5-bis(allyloxy)benzoic acid (185254-52-8)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1248/cpb.c16-00949

Reference yield: 91.0%

allyl 3,5-bis(allyloxy)benzoate (189684-08-0) → 3,5-bis(allyloxy)benzoic acid (185254-52-8)

Guidance literature:

With sodium hydroxide; In methanol; at 70 ℃; for 2h;

DOI:10.1016/j.bmcl.2006.11.053

Reference yield: 85.0%

3,5-Dihydroxybenzoic acid (99-10-5) + allyl bromide (106-95-6) → 3,5-bis(allyloxy)benzoic acid (185254-52-8)

Guidance literature:

3,5-Dihydroxybenzoic acid; allyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

With sodium hydroxide; In 1,4-dioxane; water; at 60 ℃; for 0.25h;

DOI:10.1039/c6ob00396f

upstream raw materials:

3,5-bis(2-propen-1-yloxy)benzoic acid methyl ester

1-carbomethoxy-3,5-dihydroxybenzene

allyl 3,5-bis(allyloxy)benzoate

3,5-Dihydroxybenzoic acid

Downstream raw materials:

3,5-bis(allyloxy)-N-(benzyloxy)benzamide

5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran

N-(3,5-(diallyloxy)benzoyl)-8-aminoquinoline

1,4-bis[3,5-dihydroxybenzoyloxy]benzene

Refernces

• 1、 Uchimoto, Hitomi,Ikeda, Miki,Tanida, Saori,Ohhashi, Kayo,Chihar, Yoshiko,Shigeta, Takashi,Arimitsu, Kenji,Yamashit, Masayuki,Nishide, Kiyoharu,Kawasaki, Ikuo. "Green synthesis of (R)-terbutaline for recyclable catalytic asymmetric transfer hydrogenation in ionic liquids". . p. 389 - 395. Retrieved 2017/04/14.
• 2、 -. "Synthetic method for moracin F using Suzuki coupling reaction". Paragraph 0038; 0073; 0074. . Retrieved 2017/11/09.