(+)-Sempervirol

Base Information

• Chemical Name: (+)-Sempervirol
• CAS No.: 1857-11-0
• Molecular Formula: C20H30O
• Molecular Weight: 0
• Mol file: 1857-11-0.mol

Synonyms:sempervirol;(4bS,8aS)-3-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydro-phenanthren-2-ol;

Chemical Property of (+)-Sempervirol

Chemical Property:

• PSA: 20.23000
• LogP: 5.54580

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-Sempervirol

There total 10 articles about (+)-Sempervirol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C20H32O2 (1006693-18-0) → sempervirol (1857-11-0)

Guidance literature:

With cerium(III) chloride; sodium iodide; In acetonitrile; for 30h;

DOI:10.1016/j.tetasy.2007.11.024

Reference yield:

[(S)-2,6,6-trimethylcyclohex-2-enyl]methanol (52646-93-2) → sempervirol (1857-11-0)

Guidance literature:

Multi-step reaction with 5 steps

1: DCC, H₃PO₄ / dimethylsulfoxide; benzene

2: (i) nBuLi, hexane, (ii) /BRN= 2500450/

3: H₂ / Pd-C / ethanol / Ambient temperature

4: AlCl₃ / benzene

5: BBr₃ / CH₂Cl₂

With aluminium trichloride; phosphoric acid; hydrogen; boron tribromide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; benzene;

DOI:10.1246/bcsj.52.212

Reference yield:

4-Isopropyl-3-methoxybenzoylchlorid (59665-62-2) → sempervirol (1857-11-0)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene / Heating

2: (i) nBuLi, hexane, (ii) /BRN= 2500450/

3: H₂ / Pd-C / ethanol / Ambient temperature

4: AlCl₃ / benzene

5: BBr₃ / CH₂Cl₂

With aluminium trichloride; hydrogen; boron tribromide; palladium on activated charcoal; In ethanol; dichloromethane; benzene;

DOI:10.1246/bcsj.52.212

upstream raw materials:

O-methylsempervirol

[(S)-2,6,6-trimethylcyclohex-2-enyl]methanol

4-Isopropyl-3-methoxybenzoylchlorid

1-Isopropyl-2-methoxy-4-[(E)-2-((S)-2,6,6-trimethyl-cyclohex-2-enyl)-vinyl]-benzene