Cyclobutylurea

Base Information

Chemical Name:Cyclobutylurea
CAS No.:75914-67-9
Molecular Formula:C₅H₁₀N₂O
Molecular Weight:114.147
Hs Code.:
European Community (EC) Number:877-976-7
NSC Number:117243
DSSTox Substance ID:DTXSID90297669
Wikidata:Q82038928

Synonyms:cyclobutylurea;75914-67-9;NSC117243;SCHEMBL688635;DTXSID90297669;AKOS011704874;NSC 117243;NSC-117243;EN300-260820;Z979783478

Suppliers and Price of Cyclobutylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Cyclobutylurea

Chemical Property:

Vapor Pressure:0.333mmHg at 25°C
Boiling Point:199.9°Cat760mmHg
Flash Point:74.7°C
Density:1.11g/cm³
XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:114.079312947
Heavy Atom Count:8
Complexity:98.6

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(C1)NC(=O)N

Technology Process of Cyclobutylurea

There total 2 articles about Cyclobutylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.3%

: 1118-02-1
trimethylsilyl isocyanate

: 2516-34-9
cyclobutylamine

: 75914-67-9
1-cyclobutylurea

Guidance literature:: In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 2516-34-9
cyclobutylamine

: 75914-67-9
1-cyclobutylurea

Guidance literature:: DOI:10.1021/ja01493a032

Reference yield:

: 75914-67-9
1-cyclobutylurea

: 1-cyclobutyl-6-(4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 18 h / Reflux

2: sodium nitrite; copper(ll) bromide / water; acetonitrile / 66 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.42 h / Microwave irradiation; Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; copper(ll) bromide; sodium nitrite; In 1,4-dioxane; methanol; water; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1021/acschemneuro.9b00410