(17beta)-2,4-dinitroestra-1(10),2,4-triene-3,17-diol

Base Information

Chemical Name:(17beta)-2,4-dinitroestra-1(10),2,4-triene-3,17-diol
CAS No.:20823-11-4
Molecular Formula:C₁₈H₂₂N₂O₆
Molecular Weight:362.382
Hs Code.:

Synonyms:Estra-1,3,5(10)-triene-3,17b-diol,2,4-dinitro- (8CI); Estradiol, 2,4-dinitro- (6CI);2,4-Dinitro-1,3,5(10)-estratriene-3,17b-diol;2,4-Dinitroestradiol; NSC 32056

Suppliers and Price of (17beta)-2,4-dinitroestra-1(10),2,4-triene-3,17-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (17beta)-2,4-dinitroestra-1(10),2,4-triene-3,17-diol

Chemical Property:

Vapor Pressure:1.71E-09mmHg at 25°C
Boiling Point:466.2°Cat760mmHg
Flash Point:184.8°C
Density:1.413g/cm³

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

General Description (17β)-2,4-Dinitroestra-1(10),2,4-triene-3,17-diol (also known as 2,4-dinitroestradiol) is a nitrated derivative of estradiol formed under oxidative/nitrosative stress conditions via peroxidase-mediated nitration. It is produced alongside 2-nitroestradiol and 4-nitroestradiol, with its formation favored at higher estradiol concentrations (10–300 μM) but negligible at physiological levels (e.g., 1 μM). (17beta)-2,4-dinitroestra-1(10),2,4-triene-3,17-diol arises from further nitration of 4-nitroestradiol, which exhibits greater susceptibility to nitration than its 2-nitro counterpart. While 2,4-dinitroestradiol itself was not directly tested for biological activity, related nitroestradiols (e.g., 2-nitroestradiol) demonstrated adverse effects on bovine embryo development, suggesting potential hormonal dysfunction. However, the physiological relevance of such nitration products remains uncertain due to their low yields under biologically plausible conditions.

Technology Process of (17beta)-2,4-dinitroestra-1(10),2,4-triene-3,17-diol

There total 8 articles about (17beta)-2,4-dinitroestra-1(10),2,4-triene-3,17-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 50-28-2
estradiol

: 6298-51-7
2-Nitroestratriene-3,17beta-diol

: 20823-11-4
2,4-dinitro-17β-estradiol

Guidance literature:: With nitric acid; acetic acid; at 0 - 20 ℃; for 1h;
DOI:10.1021/jo300303d

Reference yield: 16.0%

: 6936-94-3
4-Nitroestratriene-3,17beta-diol

: 20823-11-4
2,4-dinitro-17β-estradiol

Guidance literature:: With phosphate buffer; dihydrogen peroxide; sodium nitrite; horseradish peroxidase; In methanol; at 20 ℃; for 0.5h; pH=7.4;
DOI:10.1016/j.bmc.2004.03.036