Aids002770

Base Information

• Chemical Name: Aids002770
• CAS No.: 132776-21-7
• Molecular Formula: C10H12F2N2O4
• Molecular Weight: 262.2101
• Mol file: 132776-21-7.mol

Synonyms:2'-F-ribo-FLT;

Chemical Property of Aids002770

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 84.58000
• Density: 1.5g/cm³
• LogP: -0.17680

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Aids002770

There total 4 articles about Aids002770 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(5-O-benzoyl-2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)thymine (132776-20-6) → 1-(2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)thymine (132776-21-7)

Guidance literature:

With ammonia; In methanol; Ambient temperature;

DOI:10.1021/jm00109a017

Reference yield:

2,3'-anhydro-1-(5-O-benzoyl-2-deoxy-2-fluoro-D-lyxofuranosyl)thymine (132776-19-3) → 1-(2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)thymine (132776-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / HF, AlF₃ / dioxane / 1 h / 170 °C

2: 83 percent / NH₃ / methanol / Ambient temperature

With aluminum(III) fluoride; hydrogen fluoride; ammonia; In 1,4-dioxane; methanol;

DOI:10.1021/jm00109a017

Reference yield:

1-(5-O-benzoyl-2-deoxy-2-fluoro-3-O-mesyl-β-D-arabinofuranosyl)thymine (132776-18-2) → 1-(2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)thymine (132776-21-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / DBU / CH₂Cl₂ / 72 h / Ambient temperature

2: 42 percent / HF, AlF₃ / dioxane / 1 h / 170 °C

3: 83 percent / NH₃ / methanol / Ambient temperature

With aluminum(III) fluoride; hydrogen fluoride; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/jm00109a017

upstream raw materials:

1-(5-O-benzoyl-2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)thymine

2,3'-anhydro-1-(5-O-benzoyl-2-deoxy-2-fluoro-D-lyxofuranosyl)thymine

1-(5-O-benzoyl-2-deoxy-2-fluoro-3-O-mesyl-β-D-arabinofuranosyl)thymine

1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine