INDAPAMIDE RELATED COMPOUND A (50 MG) (4-CHLORO-N-(2-METHYL-INDOL-1-YL)-3-SULFAMOYLBEN-ZAMIDE) (AS)

Base Information

• Chemical Name: INDAPAMIDE RELATED COMPOUND A (50 MG) (4-CHLORO-N-(2-METHYL-INDOL-1-YL)-3-SULFAMOYLBEN-ZAMIDE) (AS)
• CAS No.: 63968-75-2
• Molecular Formula: C16H14 Cl N3 O3 S
• Molecular Weight: 363.824
• Hs Code.: 2935009090
• Mol file: 63968-75-2.mol

Synonyms:4-Chloro-3-sulfamoyl-N-(2-methyl-1H-indol-1-yl)benzamide;Dehydroindapamide

Chemical Property of INDAPAMIDE RELATED COMPOUND A (50 MG) (4-CHLORO-N-(2-METHYL-INDOL-1-YL)-3-SULFAMOYLBEN-ZAMIDE) (AS)

Chemical Property:

• Melting Point: 255-257℃
• Boiling Point: °Cat760mmHg
• PKA: 9.36±0.60(Predicted)
• Flash Point: °C
• PSA: 102.57000
• Density: 1.49g/cm³
• LogP: 4.48850
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

Indapamide impurity B ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Indapamide (M5). A dehydrogenation pathway by cytochromes P450. A metabolite of Indapamide (M5). A dehydrogenation pathway by cytochromes P450. Indapamide USP Related Compound A

Technology Process of INDAPAMIDE RELATED COMPOUND A (50 MG) (4-CHLORO-N-(2-METHYL-INDOL-1-YL)-3-SULFAMOYLBEN-ZAMIDE) (AS)

There total 2 articles about INDAPAMIDE RELATED COMPOUND A (50 MG) (4-CHLORO-N-(2-METHYL-INDOL-1-YL)-3-SULFAMOYLBEN-ZAMIDE) (AS) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

Indapamide (26807-65-8,77083-52-4) → Dehydroindapamide (63968-75-2)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; Ambient temperature; overnight;

DOI:10.1002/jhet.5570200365

Reference yield:

1-amino-3-methylindole (53406-41-0) + 3-(aminosulfonyl)-4-chlorobenzoyl chloride (70049-77-3) → Dehydroindapamide (63968-75-2)

Guidance literature:

DOI:10.1002/jhet.5570200365

Reference yield: 99.3%

Dehydroindapamide (63968-75-2) → Indapamide (26807-65-8,77083-52-4)

Guidance literature:

With sodium tetrahydroborate; hexachloroplatinic acid; hydrogen; In ethanol; at 10 ℃; for 1h;

upstream raw materials:

Indapamide

1-amino-3-methylindole

3-(aminosulfonyl)-4-chlorobenzoyl chloride

Downstream raw materials:

Indapamide