n-(5-Methyl-1,3,4-oxadiazol-2-yl)acetamide

Base Information

• Chemical Name: n-(5-Methyl-1,3,4-oxadiazol-2-yl)acetamide
• CAS No.: 5378-58-5
• Molecular Formula: C5H7N3O2
• Molecular Weight: 141.129
• NSC Number: 137939
• DSSTox Substance ID: DTXSID40300632
• Nikkaji Number: J2.521.568K
• Wikidata: Q82043856
• Mol file: 5378-58-5.mol

Synonyms:n-(5-methyl-1,3,4-oxadiazol-2-yl)acetamide;5378-58-5;NSC137939;SCHEMBL12222705;DTXSID40300632;AKOS024366066;NSC-137939

Chemical Property of n-(5-Methyl-1,3,4-oxadiazol-2-yl)acetamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.306g/cm³
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 141.053826475
• Heavy Atom Count: 10
• Complexity: 139

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NN=C(O1)NC(=O)C

Technology Process of n-(5-Methyl-1,3,4-oxadiazol-2-yl)acetamide

There total 3 articles about n-(5-Methyl-1,3,4-oxadiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-acetyl-5-acetamido-2-phenyl-2,3-dihydro-1,3,4-thiadiazole 1-oxide → 2-(acetylamino)-5-methyl-1,3,4-oxadiazole (5378-58-5) + (E)-1,2-diphenyl-ethene (103-30-0) + benzaldehyde (100-52-7)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 3h;

DOI:10.3987/R-1986-01-0021

Reference yield: 74.0%

4-acetyl-2-acetylamino-Δ2-1,3,4-thiadiazoline 1-oxide → 2-(acetylamino)-5-methyl-1,3,4-oxadiazole (5378-58-5) + (E)-1,2-diphenyl-ethene (103-30-0) + benzaldehyde (100-52-7)

Guidance literature:

With dimethyl sulfoxide; at 100 ℃;

DOI:10.1039/c39820000901

Reference yield:

2-(Acetamido)-4-acetyl-5-phenyl-Δ2-1,3,4-thiadiazoline (62236-01-5) → 2-(acetylamino)-5-methyl-1,3,4-oxadiazole (5378-58-5) + N-(5-phenyl-1,3,4-thiadiazol-2-yl)acetamide (28898-88-6)

Guidance literature:

With tert-butylhypochlorite; In methanol;

DOI:10.1039/c39820000901

upstream raw materials:

2-(Acetamido)-4-acetyl-5-phenyl-Δ²-1,3,4-thiadiazoline

Downstream raw materials:

1-(5-methyl-[1,3,4]oxadiazol-2-yl)-3-phenyl-[1,3]diazetidine-2,4-dione

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