[3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(2-methylpiperidin-1-yl)methanone

Base Information

Chemical Name:[3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(2-methylpiperidin-1-yl)methanone
CAS No.:5821-84-1
Molecular Formula:C21H20ClF3N4O2
Molecular Weight:446.456
Hs Code.:
DSSTox Substance ID:DTXSID20386752

Synonyms:5821-84-1;[3-chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(2-methylpiperidin-1-yl)methanone;DTXSID20386752;[3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl](2-methylpiperidin-1-yl)methanone

Suppliers and Price of [3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(2-methylpiperidin-1-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(2-methylpiperidin-1-yl)methanone

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.44g/cm³
XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:452.1226881
Heavy Atom Count:31
Complexity:647

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCCCN1C(=O)C2=NN3C(=CC(=NC3=C2Cl)C4=CC=C(C=C4)OC)C(F)(F)F

Technology Process of [3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(2-methylpiperidin-1-yl)methanone

There total 4 articles about [3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(2-methylpiperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32245-57-1
4H-Cyclopentaphenanthren-3-carbonsaeure-methylester

: 5821-84-1
3-Oxo-3,4,5,5a-tetrahydro-benzofluoranthen-5,5,6-tricarbonsaeure-5,5-diethylester-6-methylester

Guidance literature:: Multi-step reaction with 4 steps

1: NBS

2: (i) KOtBu, tBuOH, (ii) aq. KOH, MeOH

3: polyphosphoric acid

4: H₂SO₄

With N-Bromosuccinimide; PPA; sulfuric acid;
DOI:10.1021/ja00736a028

Reference yield:

: 5821-74-9
4-Brom-4H-cyclopentaphenanthren-3-carbonsaeure-methylester

: 5821-84-1
3-Oxo-3,4,5,5a-tetrahydro-benzofluoranthen-5,5,6-tricarbonsaeure-5,5-diethylester-6-methylester

Guidance literature:: Multi-step reaction with 3 steps

1: (i) KOtBu, tBuOH, (ii) aq. KOH, MeOH

2: polyphosphoric acid

3: H₂SO₄

With PPA; sulfuric acid;
DOI:10.1021/ja00736a028

Reference yield:

: 5821-75-0
4-(1,1-Bis-ethoxycarbonyl-2-carboxy-ethyl)-4H-cyclopentaphenanthren-3-carbonsaeure

: 5821-84-1
3-Oxo-3,4,5,5a-tetrahydro-benzofluoranthen-5,5,6-tricarbonsaeure-5,5-diethylester-6-methylester

Guidance literature:: Multi-step reaction with 2 steps

1: polyphosphoric acid

2: H₂SO₄

With PPA; sulfuric acid;
DOI:10.1021/ja00736a028